Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma

C. R. Parker, E. R. Simpson, D. W. Bilheimer, K. Leveno, B. R. Carr, P. C. MacDonald

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.

Original languageEnglish (US)
Pages (from-to)514-516
Number of pages3
JournalScience
Volume208
Issue number4443
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General

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