Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma

C. R. Parker, E. R. Simpson, D. W. Bilheimer, K. Leveno, B. R. Carr, P. C. MacDonald

Research output: Contribution to journalArticle

Abstract

A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.

Original languageEnglish (US)
Pages (from-to)512-514
Number of pages3
JournalScience
Volume208
Issue number4443
DOIs
StatePublished - 1980

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Dehydroepiandrosterone Sulfate
LDL Cholesterol
VLDL Cholesterol
Umbilical Cord
Genetic Predisposition to Disease
Hypercholesterolemia
HDL Cholesterol
Lipoproteins
Estrogens
cholesteryl sulfate

ASJC Scopus subject areas

  • General

Cite this

Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma. / Parker, C. R.; Simpson, E. R.; Bilheimer, D. W.; Leveno, K.; Carr, B. R.; MacDonald, P. C.

In: Science, Vol. 208, No. 4443, 1980, p. 512-514.

Research output: Contribution to journalArticle

Parker, C. R. ; Simpson, E. R. ; Bilheimer, D. W. ; Leveno, K. ; Carr, B. R. ; MacDonald, P. C. / Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma. In: Science. 1980 ; Vol. 208, No. 4443. pp. 512-514.
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AU - Carr, B. R.

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