Abstract
The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1586-1588 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 148 |
| Issue number | 11 |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
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Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients. / Adinoff, Bryon; Nemeroff, Charles B.; Bissette, Garth; Martin, Peter R.; Linnoila, Markku.
In: American Journal of Psychiatry, Vol. 148, No. 11, 1991, p. 1586-1588.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients
AU - Adinoff, Bryon
AU - Nemeroff, Charles B.
AU - Bissette, Garth
AU - Martin, Peter R.
AU - Linnoila, Markku
PY - 1991
Y1 - 1991
N2 - The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.
AB - The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.
UR - http://www.scopus.com/inward/record.url?scp=0026072424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026072424&partnerID=8YFLogxK
M3 - Article
C2 - 1656797
AN - SCOPUS:0026072424
VL - 148
SP - 1586
EP - 1588
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 11
ER -