Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients

Bryon Adinoff; Charles B. Nemeroff; Garth Bissette; Peter R. Martin; Markku Linnoila

doi:10.1176/ajp.148.11.1586

Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients

Bryon Adinoff, Charles B. Nemeroff, Garth Bissette, Peter R. Martin, Markku Linnoila

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.

Original language	English (US)
Pages (from-to)	1586-1588
Number of pages	3
Journal	American Journal of Psychiatry
Volume	148
Issue number	11
DOIs	https://doi.org/10.1176/ajp.148.11.1586
State	Published - Jan 1 1991

ASJC Scopus subject areas

Psychiatry and Mental health

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abstract = "The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.",

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AU - Martin, Peter R.

AU - Linnoila, Markku

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AB - The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.

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Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients

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