Investigating the pretreatment miRNA expression patterns of advanced hepatocellular carcinoma patients in association with response to TACE treatment

Medhat S. El-Halawany, Heba M. Ismail, Ahmed A. Zeeneldin, Ammar Elfiky, Marwa Tantawy, Mohamed H. Kobaisi, Ikram Hamed, Abdel Hady A. Abdel Wahab

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options. Transarterial chemoembolization (TACE) using chemotherapy agents - doxorubicin and cisplatin - is an accepted treatment option for locally advanced hepatocellular carcinoma. In the current study, we analyzed the expression pattern of a selected panel of 94 miRNAs in archival samples that were collected prior to treatment from 15 Egyptian patients diagnosed with advanced hepatocelleular carcinoma. We observed an overall increase in miRNA expression in HCC samples compared with normal subjects. Out of 94 examined miRNAs, 53 were significantly upregulated while 3 miRNAs were downregulated in HCC samples compared to normal liver samples. Comparing the pretreatment miRNA expression profiles in HCC patients and the patients response to TACE treatment resulted in the identification of a set of 12 miRNAs that are significantly upregulated in nonresponders group. This miRNA panel includes miR-10a-1, miR-23a-1, miR-24, miR-26a, miR-27a, miR-30c, miR-30e, miR-106b, miR-133b, miR-199a, miR-199-3p, and miR-200b. Furthermore, we observed that a panel of 10 miRNAs was significantly associated with patients' survival status at 1 year. These results highlight the potential implications of pretreatment miRNAs expression profiling in prediction of the patients' response to TACE treatment in liver cancer.

Original languageEnglish (US)
Article number649750
JournalBioMed Research International
Volume2015
DOIs
StatePublished - Feb 25 2015
Externally publishedYes

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MicroRNAs
Hepatocellular Carcinoma
Therapeutics
Liver
Chemotherapy
Liver Neoplasms
Doxorubicin
Cisplatin
Down-Regulation
Carcinoma
Drug Therapy
Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Investigating the pretreatment miRNA expression patterns of advanced hepatocellular carcinoma patients in association with response to TACE treatment. / El-Halawany, Medhat S.; Ismail, Heba M.; Zeeneldin, Ahmed A.; Elfiky, Ammar; Tantawy, Marwa; Kobaisi, Mohamed H.; Hamed, Ikram; Abdel Wahab, Abdel Hady A.

In: BioMed Research International, Vol. 2015, 649750, 25.02.2015.

Research output: Contribution to journalArticle

El-Halawany, Medhat S. ; Ismail, Heba M. ; Zeeneldin, Ahmed A. ; Elfiky, Ammar ; Tantawy, Marwa ; Kobaisi, Mohamed H. ; Hamed, Ikram ; Abdel Wahab, Abdel Hady A. / Investigating the pretreatment miRNA expression patterns of advanced hepatocellular carcinoma patients in association with response to TACE treatment. In: BioMed Research International. 2015 ; Vol. 2015.
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