Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response

Laura M. Fiori, Juan Pablo Lopez, Stéphane Richard-Devantoy, Marcelo Berlim, Eduardo Chachamovich, Fabrice Jollant, Jane Foster, Susan Rotzinger, Sidney H. Kennedy, Gustavo Turecki

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Background: Major depressive disorder is a debilitating illness, which is most commonly treated with antidepressant drugs. As the majority of patients do not respond on their first trial, there is great interest in identifying biological factors that indicate the most appropriate treatment for each patient. Studies suggest that microRNA represent excellent biomarkers to predict antidepressant response. Methods: We investigated the expression of miR-1202, miR-135a, and miR-16 in peripheral blood from 2 cohorts of depressed patients who received 8 weeks of antidepressant therapy. Expression was quantified at baseline and after treatment, and its relationship to treatment response and depressive symptoms was assessed. Results: In both cohorts, responders displayed lower baseline miR-1202 levels compared with nonresponders, which increased following treatment. Conclusions: Ultimately, our results support the involvement of microRNA in antidepressant response and suggest that quantification of their levels in peripheral samples represents a valid approach to informing treatment decisions.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Volume20
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Keywords

  • Antidepressant response
  • Major depressive disorder
  • Microrna

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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