Investigation of native fluorescence spectral difference among prostate cancer cell lines with different risk levels

Yang Pu, Jianpeng Xue, Baogang Xu, Wubao Wang, Yueqing Gu, Rui Tang, S. Achilefu, Ellen Ackerstaff, Jason A. Koutcher, R. R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The alteration of native fluorophores among different types of cancer cell lines was investigated by the fluorescence spectroscopy. Different types of cancer cell lines with different risk levels, such as moderate metastatic (DU-145) and advanced metastatic (PC-3) cell lines as well as normal cell line (Fibroblast), were excited by the selective excitation wavelength of 300 nm to explore changes of the relative contents of tryptophan and NADH using principal component analysis (PCA). The higher relative content of tryptophan was observed in the advanced metastatic cancer cell lines in comparison with the moderate metastatic and non aggressive cell lines.

Original languageEnglish (US)
Title of host publicationOptical Biopsy XI
DOIs
StatePublished - 2013
Externally publishedYes
EventConference on Optical Biopsy XI - San Francisco, CA, United States
Duration: Feb 5 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8577
ISSN (Print)1605-7422

Conference

ConferenceConference on Optical Biopsy XI
Country/TerritoryUnited States
CitySan Francisco, CA
Period2/5/132/6/13

Keywords

  • DU-145
  • Fibroblast
  • Native fluorescence
  • PC-3
  • cancer cell lines with different risk levels

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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