Investigation of phase-contrast magnetic resonance imaging underestimation of turbulent flow through the aortic valve phantom: experimental and computational study using lattice Boltzmann method

Radek Fučík, Radek Galabov, Petr Pauš, Pavel Eichler, Jakub Klinkovský, Robert Straka, Jaroslav Tintěra, Radomír Chabiniok

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The accuracy of phase-contrast magnetic resonance imaging (PC-MRI) measurement is investigated using a computational fluid dynamics (CFD) model with the objective to determine the magnitude of the flow underestimation due to turbulence behind a narrowed valve in a phantom experiment. Materials and methods: An acrylic stationary flow phantom is used with three insertable plates mimicking aortic valvular stenoses of varying degrees. Positive and negative horizontal fluxes are measured at equidistant slices using standard PC-MRI sequences by 1.5T and 3T systems. The CFD model is based on the 3D lattice Boltzmann method (LBM). The experimental and simulated data are compared using the Bland-Altman-derived limits of agreement. Based on the LBM results, the turbulence is quantified and confronted with the level of flow underestimation. Results: LBM gives comparable results to PC-MRI for valves up to moderate stenosis on both field strengths. The flow magnitude through a severely stenotic valve was underestimated due to signal void in the regions of turbulent flow behind the valve, consistently with the level of quantified turbulence intensity. Discussion: Flow measured by PC-MRI is affected by noise and turbulence. LBM can simulate turbulent flow efficiently and accurately, it has therefore the potential to improve clinical interpretation of PC-MRI.

Original languageEnglish (US)
Pages (from-to)649-662
Number of pages14
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume33
Issue number5
DOIs
StatePublished - Oct 1 2020

Keywords

  • Aortic valve stenosis
  • Computational fluid dynamics
  • Flow phantom
  • Lattice Boltzmann method
  • Phase-contrast MRI

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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