Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis

Takeji Umemura, Eiji Tanaka, George Ostapowicz, Kevin E. Brown, Stefan Heringlake, Nicolaos C. Tassopoulos, Richard Y H Wang, Anthony E T Yeo, J. Wai Kuo Shih, Koji Orii, Neal S. Young, Angelos Hatzakis, Michael P. Manns, William M. Lee, Kendo Kiyosawa, Harvey J. Alter

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Abstract

SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.

Original languageEnglish (US)
Pages (from-to)1545-1552
Number of pages8
JournalJournal of Infectious Diseases
Volume188
Issue number10
DOIs
StatePublished - Nov 15 2003

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Torque teno virus
Hepatitis E
Acute Liver Failure
Aplastic Anemia
Virus Diseases
Hepatitis
Hepatitis A
Chronic Hepatitis B
Chronic Hepatitis C
Liver Diseases
Healthy Volunteers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis. / Umemura, Takeji; Tanaka, Eiji; Ostapowicz, George; Brown, Kevin E.; Heringlake, Stefan; Tassopoulos, Nicolaos C.; Wang, Richard Y H; Yeo, Anthony E T; Shih, J. Wai Kuo; Orii, Koji; Young, Neal S.; Hatzakis, Angelos; Manns, Michael P.; Lee, William M.; Kiyosawa, Kendo; Alter, Harvey J.

In: Journal of Infectious Diseases, Vol. 188, No. 10, 15.11.2003, p. 1545-1552.

Research output: Contribution to journalArticle

Umemura, T, Tanaka, E, Ostapowicz, G, Brown, KE, Heringlake, S, Tassopoulos, NC, Wang, RYH, Yeo, AET, Shih, JWK, Orii, K, Young, NS, Hatzakis, A, Manns, MP, Lee, WM, Kiyosawa, K & Alter, HJ 2003, 'Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis', Journal of Infectious Diseases, vol. 188, no. 10, pp. 1545-1552. https://doi.org/10.1086/379216
Umemura, Takeji ; Tanaka, Eiji ; Ostapowicz, George ; Brown, Kevin E. ; Heringlake, Stefan ; Tassopoulos, Nicolaos C. ; Wang, Richard Y H ; Yeo, Anthony E T ; Shih, J. Wai Kuo ; Orii, Koji ; Young, Neal S. ; Hatzakis, Angelos ; Manns, Michael P. ; Lee, William M. ; Kiyosawa, Kendo ; Alter, Harvey J. / Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis. In: Journal of Infectious Diseases. 2003 ; Vol. 188, No. 10. pp. 1545-1552.
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