Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis

Takeji Umemura, Eiji Tanaka, George Ostapowicz, Kevin E. Brown, Stefan Heringlake, Nicolaos C. Tassopoulos, Richard Y H Wang, Anthony E T Yeo, J. Wai Kuo Shih, Koji Orii, Neal S. Young, Angelos Hatzakis, Michael P. Manns, William M. Lee, Kendo Kiyosawa, Harvey J. Alter

Research output: Contribution to journalArticle

62 Scopus citations


SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.

Original languageEnglish (US)
Pages (from-to)1545-1552
Number of pages8
JournalJournal of Infectious Diseases
Issue number10
Publication statusPublished - Nov 15 2003


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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