@article{b16b7d4bb6ed40f89f1ecbeec2e3ad91,
title = "Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis",
abstract = "SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.",
author = "Takeji Umemura and Eiji Tanaka and George Ostapowicz and Brown, {Kevin E.} and Stefan Heringlake and Tassopoulos, {Nicolaos C.} and Wang, {Richard Y H} and Yeo, {Anthony E T} and Shih, {J. Wai Kuo} and Koji Orii and Young, {Neal S.} and Angelos Hatzakis and Manns, {Michael P.} and Lee, {William M.} and Kendo Kiyosawa and Alter, {Harvey J.}",
note = "Funding Information: 1Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and 2Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland; 3Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas; 4Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan; 5Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany; 6First Department of Medicine, Western Attica General Hospital, and 7Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece",
year = "2003",
month = nov,
day = "15",
doi = "10.1086/379216",
language = "English (US)",
volume = "188",
pages = "1545--1552",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}