Investigation of stroke in sickle cell disease by1H nuclear magnetic resonance spectroscopy

Z. Wang, A. R. Bogdan, R. A. Zimmerman, D. A. Gusnard, J. S. Leigh, K. Ohene-Frempong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Localized proton nuclear magnetic resonance spectroscopy (MRS), obtained with stimulated echo and spin echo sequences, MR imaging (MRI) and MR angiography (MRA) were used to study the brain in 13 children and adolescents with sickle cell disease. Regions of interest (ROI) studied by MRS included regions appearing normal on MRI as well as regions showing complications of sickle cell disease, including focal deep white matter areas of high signal intensity (deep white matter ischemia, DWMI) seen on long TR images, focal atrophic brain areas, and infarcts. The findings in these studies are summarized as follows: Normal-appearing regions on MRI have normal MRS. In ROI including small areas of DWMI, lactate elevation was not detected, but the levels of N-acetyl-aspartate (NAA) appeared slightly elevated. In areas of DWMI 1-2 cm in size, reduced blood flow could be seen on MRA and lactate elevation could be detected with MRS. When blood flow to a DWMI region was normal, NAA was reduced and there was little lactate elevation, as cell death had already occurred. ROI consisting of atrophic tissue had reduced NAA levels but total creatine levels were not changed. Sometimes lipids, presumably from broken cell membrane, could be detected. In regions of past massive stroke, all metabolites were absent except for small amounts of lactate or lipids.

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalNeuroradiology
Volume35
Issue number1
DOIs
StatePublished - Jan 1992

Fingerprint

Sickle Cell Anemia
Magnetic Resonance Spectroscopy
Stroke
Lactic Acid
Ischemia
Angiography
Lipids
Creatine
Brain
Cell Death
Cell Membrane
White Matter
N-acetylaspartate

Keywords

  • Cerebrovascular accident
  • Magnetic resonance angiography
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Sickle cell disease
  • Stroke

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Wang, Z., Bogdan, A. R., Zimmerman, R. A., Gusnard, D. A., Leigh, J. S., & Ohene-Frempong, K. (1992). Investigation of stroke in sickle cell disease by1H nuclear magnetic resonance spectroscopy. Neuroradiology, 35(1), 57-65. https://doi.org/10.1007/BF00588281

Investigation of stroke in sickle cell disease by1H nuclear magnetic resonance spectroscopy. / Wang, Z.; Bogdan, A. R.; Zimmerman, R. A.; Gusnard, D. A.; Leigh, J. S.; Ohene-Frempong, K.

In: Neuroradiology, Vol. 35, No. 1, 01.1992, p. 57-65.

Research output: Contribution to journalArticle

Wang, Z, Bogdan, AR, Zimmerman, RA, Gusnard, DA, Leigh, JS & Ohene-Frempong, K 1992, 'Investigation of stroke in sickle cell disease by1H nuclear magnetic resonance spectroscopy', Neuroradiology, vol. 35, no. 1, pp. 57-65. https://doi.org/10.1007/BF00588281
Wang, Z. ; Bogdan, A. R. ; Zimmerman, R. A. ; Gusnard, D. A. ; Leigh, J. S. ; Ohene-Frempong, K. / Investigation of stroke in sickle cell disease by1H nuclear magnetic resonance spectroscopy. In: Neuroradiology. 1992 ; Vol. 35, No. 1. pp. 57-65.
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