Involvement of Brd4 in different steps of the papillomavirus life cycle

Thomas Iftner, Juliane Haedicke-Jarboui, Shwu Yuan Wu, Cheng Ming Chiang

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4’s activity in order to create a facilitating environment for the viral life cycle. Brd4, in association with the major viral regulatory protein E2, is involved in multiple steps of the PV life cycle including replication initiation, viral gene transcription, and viral genome segregation and maintenance. Phosphorylation of Brd4, regulated by casein kinase II (CK2) and protein phosphatase 2A (PP2A), is critical for viral gene transcription as well as E1- and E2-dependent origin replication. Thus, pharmacological agents regulating Brd4 phosphorylation and inhibitors blocking phospho-Brd4 functions are promising candidates for therapeutic intervention in treating human papillomavirus (HPV) infections as well as associated disease.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalVirus Research
Volume231
DOIs
StatePublished - Mar 2 2017

Keywords

  • Brd4
  • E2 protein
  • Papillomavirus life cycle
  • Papillomavirus replication
  • Papillomavirus transcription

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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