Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions

Ricardo José Soares, Stefano Cagnin, Francesco Chemello, Matteo Silvestrin, Antonio Musaro, Cristiano De Pitta, Gerolamo Lanfranchi, Marco Sandri

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions.

Original languageEnglish (US)
Pages (from-to)21909-21925
Number of pages17
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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