TY - JOUR
T1 - Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions
AU - Soares, Ricardo José
AU - Cagnin, Stefano
AU - Chemello, Francesco
AU - Silvestrin, Matteo
AU - Musaro, Antonio
AU - De Pitta, Cristiano
AU - Lanfranchi, Gerolamo
AU - Sandri, Marco
PY - 2014/8/8
Y1 - 2014/8/8
N2 - Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions.
AB - Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions.
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U2 - 10.1074/jbc.M114.561845
DO - 10.1074/jbc.M114.561845
M3 - Article
C2 - 24891504
AN - SCOPUS:84905844116
VL - 289
SP - 21909
EP - 21925
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 32
ER -