Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions

Ricardo José Soares; Stefano Cagnin; Francesco Chemello; Matteo Silvestrin; Antonio Musaro; Cristiano De Pitta; Gerolamo Lanfranchi; Marco Sandri

doi:10.1074/jbc.M114.561845

Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions

Ricardo José Soares, Stefano Cagnin, Francesco Chemello, Matteo Silvestrin, Antonio Musaro, Cristiano De Pitta, Gerolamo Lanfranchi, Marco Sandri

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions.

Original language	English (US)
Pages (from-to)	21909-21925
Number of pages	17
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.561845
State	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions. / Soares, Ricardo José; Cagnin, Stefano; Chemello, Francesco; Silvestrin, Matteo; Musaro, Antonio; De Pitta, Cristiano; Lanfranchi, Gerolamo; Sandri, Marco.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 21909-21925.

Research output: Contribution to journal › Article › peer-review

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AU - Musaro, Antonio

AU - De Pitta, Cristiano

AU - Lanfranchi, Gerolamo

AU - Sandri, Marco

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