Abstract
Background: MicroRNAs are important modulators of gene expression but their role in the atrophy program and in muscle loss is unknown. Results: miRNA-206 and miRNA-21 are critical for regulation of the atrophy program after denervation. Conclusion: miRNAs are important for the fine-tuning of the atrophy program. Significance: Modulating miRNA expression is a novel potential therapeutic approach for counteracting muscle loss and weakness in catabolic conditions.
Original language | English (US) |
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Pages (from-to) | 21909-21925 |
Number of pages | 17 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 32 |
DOIs | |
State | Published - Aug 8 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology