Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

Damien Lanfray, Alexandre Caron, Marie Claude Roy, Mathieu Laplante, Fabrice Morin, Jérôme Leprince, Marie Christine Tonon, Denis Richard

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.

Original languageEnglish (US)
Article numbere11742
JournaleLife
Volume5
Issue numberFEBRUARY2016
DOIs
StatePublished - Feb 15 2016
Externally publishedYes

Fingerprint

Diazepam Binding Inhibitor
Acyl Coenzyme A
Melanocortins
Energy Metabolism
Neurons
Arcuate Nucleus of Hypothalamus
Eating
Leptin
Protein Isoforms
GABAergic Neurons
Pro-Opiomelanocortin
G-Protein-Coupled Receptors
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Obesity
Genes
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lanfray, D., Caron, A., Roy, M. C., Laplante, M., Morin, F., Leprince, J., ... Richard, D. (2016). Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. eLife, 5(FEBRUARY2016), [e11742]. https://doi.org/10.7554/eLife.11742

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. / Lanfray, Damien; Caron, Alexandre; Roy, Marie Claude; Laplante, Mathieu; Morin, Fabrice; Leprince, Jérôme; Tonon, Marie Christine; Richard, Denis.

In: eLife, Vol. 5, No. FEBRUARY2016, e11742, 15.02.2016.

Research output: Contribution to journalArticle

Lanfray, D, Caron, A, Roy, MC, Laplante, M, Morin, F, Leprince, J, Tonon, MC & Richard, D 2016, 'Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice', eLife, vol. 5, no. FEBRUARY2016, e11742. https://doi.org/10.7554/eLife.11742
Lanfray, Damien ; Caron, Alexandre ; Roy, Marie Claude ; Laplante, Mathieu ; Morin, Fabrice ; Leprince, Jérôme ; Tonon, Marie Christine ; Richard, Denis. / Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. In: eLife. 2016 ; Vol. 5, No. FEBRUARY2016.
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