Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

Damien Lanfray, Alexandre Caron, Marie Claude Roy, Mathieu Laplante, Fabrice Morin, Jérôme Leprince, Marie Christine Tonon, Denis Richard

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.

Original languageEnglish (US)
Article numbere11742
JournaleLife
Volume5
Issue numberFEBRUARY2016
DOIs
StatePublished - Feb 15 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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