Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Ichiyo Matsuzaki, Takeshi Sakurai, Kaiko Kunii, Toshiaki Nakamura, Masashi Yanagisawa, Katsutoshi Goto

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalRegulatory Peptides
Volume104
Issue number1-3
DOIs
StatePublished - Mar 15 2002

Keywords

  • Behavior
  • Dopamine
  • Locomotor activity
  • Orexin
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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