Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Ichiyo Matsuzaki; Takeshi Sakurai; Kaiko Kunii; Toshiaki Nakamura; Masashi Yanagisawa; Katsutoshi Goto

doi:10.1016/S0167-0115(01)00355-X

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Ichiyo Matsuzaki, Takeshi Sakurai, Kaiko Kunii, Toshiaki Nakamura, Masashi Yanagisawa, Katsutoshi Goto

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.

Original language	English (US)
Pages (from-to)	119-123
Number of pages	5
Journal	Regulatory Peptides
Volume	104
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-0115(01)00355-X
State	Published - Mar 15 2002

Keywords

Behavior
Dopamine
Locomotor activity
Orexin
Serotonin

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/S0167-0115(01)00355-X

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title = "Involvement of the serotonergic system in orexin-induced behavioral alterations in rats",

abstract = "We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.",

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AU - Sakurai, Takeshi

AU - Kunii, Kaiko

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AU - Yanagisawa, Masashi

AU - Goto, Katsutoshi

PY - 2002/3/15

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N2 - We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.

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KW - Behavior

KW - Dopamine

KW - Locomotor activity

KW - Orexin

KW - Serotonin

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Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Abstract

Keywords

ASJC Scopus subject areas

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