Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Ichiyo Matsuzaki, Takeshi Sakurai, Kaiko Kunii, Toshiaki Nakamura, Masashi Yanagisawa, Katsutoshi Goto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalRegulatory Peptides
Volume104
Issue number1-3
DOIs
StatePublished - Mar 15 2002

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Rats
Metergoline
Ritanserin
Serotonin Antagonists
Haloperidol
Washing
Grooming
Locomotion
Dogs
Orexins

Keywords

  • Behavior
  • Dopamine
  • Locomotor activity
  • Orexin
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats. / Matsuzaki, Ichiyo; Sakurai, Takeshi; Kunii, Kaiko; Nakamura, Toshiaki; Yanagisawa, Masashi; Goto, Katsutoshi.

In: Regulatory Peptides, Vol. 104, No. 1-3, 15.03.2002, p. 119-123.

Research output: Contribution to journalArticle

Matsuzaki, Ichiyo ; Sakurai, Takeshi ; Kunii, Kaiko ; Nakamura, Toshiaki ; Yanagisawa, Masashi ; Goto, Katsutoshi. / Involvement of the serotonergic system in orexin-induced behavioral alterations in rats. In: Regulatory Peptides. 2002 ; Vol. 104, No. 1-3. pp. 119-123.
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