TY - JOUR
T1 - Inwardly rectifying Kir3.1 subunit knockdown impairs learning and memory in an olfactory associative task in rat
AU - Kourrich, Saïd
AU - Masmejean, Frédérique
AU - Martin-Eauclaire, Marie France
AU - Soumireu-Mourat, Bernard
AU - Mourre, Christiane
PY - 2003/5/12
Y1 - 2003/5/12
N2 - Inward-rectifier potassium channels gated by the direct action of G proteins are activated or inhibited by numerous neurotransmitters and they modulate neuronal excitability. Using an olfactory associative task, the effect of Kir3.1 subunit knockdown was tested on learning and memory. Repeated intracerebroventricular injections of antisense oligodeoxyribonucleotide to the Kir3.1 subunit significantly reduced hippocampal expression of its mRNA target determined by Western blotting. The antisense knockdown had no effect on locomotor and drinking activity or on attention processes. The reduction in Kir3.1 subunit impaired the learning of the odor associations and the procedural side of the task. This reduction correlated with the performance impairment. The results suggest that Kir3.1 channel activity is implicated in the memory processes.
AB - Inward-rectifier potassium channels gated by the direct action of G proteins are activated or inhibited by numerous neurotransmitters and they modulate neuronal excitability. Using an olfactory associative task, the effect of Kir3.1 subunit knockdown was tested on learning and memory. Repeated intracerebroventricular injections of antisense oligodeoxyribonucleotide to the Kir3.1 subunit significantly reduced hippocampal expression of its mRNA target determined by Western blotting. The antisense knockdown had no effect on locomotor and drinking activity or on attention processes. The reduction in Kir3.1 subunit impaired the learning of the odor associations and the procedural side of the task. This reduction correlated with the performance impairment. The results suggest that Kir3.1 channel activity is implicated in the memory processes.
KW - Behavior
KW - Girk1 channel
KW - Hippocampus
KW - Learning and memory processes
KW - Odor-reward association
KW - Potassium channel
KW - Synaptic plasticity
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U2 - 10.1016/S0169-328X(03)00096-2
DO - 10.1016/S0169-328X(03)00096-2
M3 - Article
C2 - 12750011
AN - SCOPUS:0038582528
SN - 0169-328X
VL - 113
SP - 97
EP - 106
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -