Abstract
The curve describing the uptake of 45Ca by bone powder or by synthetic hydroxyapatite shows an initial rapid fall in radioactivity of solution followed by a mono-exponential decline at a slower rate. Wash-out experiments were performed on the labelled crystals before and during the period of mono-exponential fall by resuspending the crystals, collected by filtration, in medium free of isotope. More than 80% of radiocalcium could be removed from the crystal phase by this procedure regardless of the period of labelling. Results from published reports are interpreted to show that “back-diffusion” of isotope from bone into solution is operative only at a certain region of the uptake curve; our studies contradict this interpretation.
Original language | English (US) |
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Pages (from-to) | 126-130 |
Number of pages | 5 |
Journal | Proceedings of the Society for Experimental Biology and Medicine |
Volume | 126 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1967 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology