Abstract
The effect of Mg2+, citrate3-, F- and SO42- on the exchange of45Ca2+ and32PO43- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO43- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO43- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO43- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO42- did not significantly affect the solubility, dissolution, or growth of bone mineral.
Original language | English (US) |
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Pages (from-to) | 69-77 |
Number of pages | 9 |
Journal | Calcified Tissue Research |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1 1969 |
Keywords
- Bone mineral
- Citrate
- Fluoride
- Ion exchange
- Magnesium
ASJC Scopus subject areas
- Endocrinology