Ionic interaction with bone mineral - V. Effect of Mg2+, citrate3-, F- and SO42- on the solubility, dissolution and growth of bone mineral

Charles Y C Pak, Esther C. Diller

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The effect of Mg2+, citrate3-, F- and SO42- on the exchange of45Ca2+ and32PO43- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO43- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO43- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO43- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO42- did not significantly affect the solubility, dissolution, or growth of bone mineral.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalCalcified Tissue Research
Issue number1
StatePublished - Dec 1 1969



  • Bone mineral
  • Citrate
  • Fluoride
  • Ion exchange
  • Magnesium

ASJC Scopus subject areas

  • Endocrinology

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