Ionic interaction with bone mineral - V. Effect of Mg2+, citrate3-, F- and SO4 2- on the solubility, dissolution and growth of bone mineral

Charles Y C Pak, Esther C. Diller

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The effect of Mg2+, citrate3-, F- and SO4 2- on the exchange of45Ca2+ and32PO4 3- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO4 3- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO4 3- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO4 3- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO4 2- did not significantly affect the solubility, dissolution, or growth of bone mineral.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalCalcified Tissue Research
Volume4
Issue number1
DOIs
StatePublished - Dec 1969

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Bone Development
Solubility
Minerals
ethylenediamine
Bone and Bones
Liquid Crystals

Keywords

  • Bone mineral
  • Citrate
  • Fluoride
  • Ion exchange
  • Magnesium

ASJC Scopus subject areas

  • Endocrinology
  • Medicine(all)

Cite this

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title = "Ionic interaction with bone mineral - V. Effect of Mg2+, citrate3-, F- and SO4 2- on the solubility, dissolution and growth of bone mineral",
abstract = "The effect of Mg2+, citrate3-, F- and SO4 2- on the exchange of45Ca2+ and32PO4 3- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO4 3- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO4 3- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO4 3- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO4 2- did not significantly affect the solubility, dissolution, or growth of bone mineral.",
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author = "Pak, {Charles Y C} and Diller, {Esther C.}",
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T1 - Ionic interaction with bone mineral - V. Effect of Mg2+, citrate3-, F- and SO4 2- on the solubility, dissolution and growth of bone mineral

AU - Pak, Charles Y C

AU - Diller, Esther C.

PY - 1969/12

Y1 - 1969/12

N2 - The effect of Mg2+, citrate3-, F- and SO4 2- on the exchange of45Ca2+ and32PO4 3- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO4 3- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO4 3- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO4 3- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO4 2- did not significantly affect the solubility, dissolution, or growth of bone mineral.

AB - The effect of Mg2+, citrate3-, F- and SO4 2- on the exchange of45Ca2+ and32PO4 3- with the mineral phase of bone (ethylenediamine-extracted) was determined under physiological conditions. Mg2+ substituted for Ca2+ at the adherent liquid film (hydration shell), while citrate3- displaced PO4 3- from both the adherent liquid film and the crystal surface. These bone-seeking elements thus increased the apparent solubility of bone mineral. In contrast, F- markedly reduced the concentration of Ca2+ and PO4 3- in both the ambient solution and the adherent liquid film, probably by inducing the formation of a CaF2 boundary layer at the crystal surface. There was a net uptake of Ca2+ and PO4 3- by the solids phase in the presence of Mg2+ and F-, but not in citrate3- solutions. SO4 2- did not significantly affect the solubility, dissolution, or growth of bone mineral.

KW - Bone mineral

KW - Citrate

KW - Fluoride

KW - Ion exchange

KW - Magnesium

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