Irritation by hydrophilic ointment under occlusion

P. R. Bergstresser, W. H. Eaglstein

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Abstract

In the present study it was shown that hydrophilic ointment and a similar vehicle containing 1% sodium lauryl sulfate invariably produce contact irritant dermatitis when they are occluded 16 hours a day for more than 3 days. Sodium lauryl sulfate is the provocative agent. Previous experimental work on sodium lauryl sulfate suggests that denaturation of epidermal proteins and subsequent loss of the epidermal barrier are the likely mechanisms. Less irritating emulsifiers, or concentrations of sodium lauryl sulfate less than 1%, should be used in topical products, especially those that might be used under occlusion.

Original languageEnglish (US)
Pages (from-to)218-219
Number of pages2
JournalArchives of Dermatology
Volume108
Issue number2
DOIs
Publication statusPublished - 1973

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ASJC Scopus subject areas

  • Dermatology

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