Abstract
Objective: It is stated commonly that the earlier in pregnancy bacterial vaginosis is diagnosed, the greater is the increase in risk of preterm birth compared with women without bacterial vaginosis. However, this contention is based on small numbers of women. Study design: In this analysis of 12,937 women who were screened for bacterial vaginosis as part of a previously conducted clinical trial, the odds ratio of preterm birth (<7 weeks of gestation) for asymptomatic bacterial vaginosis-positive versus bacterial vaginosis-negative women was evaluated among women who were screened from 8 to 22 weeks of gestation. Results: The odds ratio of preterm birth among bacterial vaginosis-positive versus bacterial vaginosis-negative women ranged from 1.1 to 1.6 and did not vary significantly according to the gestational age at which bacterial vaginosis was screened. The odds ratio for preterm birth did not vary significantly by gestational age at diagnosis when bacterial vaginosis was subdivided into Gram stain score 7 to 8 or 9 to 10. Conclusion: Although bacterial vaginosis was associated with an increased risk of preterm birth, the gestational age at which bacterial vaginosis was screened for and diagnosed did not influence the increase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 470-477 |
| Number of pages | 8 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 192 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2005 |
Fingerprint
Keywords
- Bacterial vaginosis
- Gram stain
- Preterm birth
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation? / Klebanoff, Mark A.; Hillier, Sharon L.; Nugent, Robert P.; MacPherson, Cora A.; Hauth, John C.; Carey, J. Christopher; Harper, Margaret; Wapner, Ronald J.; Trout, Wayne; Moawad, Atef; Leveno, Kenneth J.; Miodovnik, Menachem; Sibai, Baha M.; VanDorsten, J. Peter; Dombrowski, Mitchell P.; O'Sullivan, Mary J.; Varner, Michael; Langer, Oded.
In: American Journal of Obstetrics and Gynecology, Vol. 192, No. 2, 02.2005, p. 470-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation?
AU - Klebanoff, Mark A.
AU - Hillier, Sharon L.
AU - Nugent, Robert P.
AU - MacPherson, Cora A.
AU - Hauth, John C.
AU - Carey, J. Christopher
AU - Harper, Margaret
AU - Wapner, Ronald J.
AU - Trout, Wayne
AU - Moawad, Atef
AU - Leveno, Kenneth J.
AU - Miodovnik, Menachem
AU - Sibai, Baha M.
AU - VanDorsten, J. Peter
AU - Dombrowski, Mitchell P.
AU - O'Sullivan, Mary J.
AU - Varner, Michael
AU - Langer, Oded
PY - 2005/2
Y1 - 2005/2
N2 - Objective: It is stated commonly that the earlier in pregnancy bacterial vaginosis is diagnosed, the greater is the increase in risk of preterm birth compared with women without bacterial vaginosis. However, this contention is based on small numbers of women. Study design: In this analysis of 12,937 women who were screened for bacterial vaginosis as part of a previously conducted clinical trial, the odds ratio of preterm birth (<7 weeks of gestation) for asymptomatic bacterial vaginosis-positive versus bacterial vaginosis-negative women was evaluated among women who were screened from 8 to 22 weeks of gestation. Results: The odds ratio of preterm birth among bacterial vaginosis-positive versus bacterial vaginosis-negative women ranged from 1.1 to 1.6 and did not vary significantly according to the gestational age at which bacterial vaginosis was screened. The odds ratio for preterm birth did not vary significantly by gestational age at diagnosis when bacterial vaginosis was subdivided into Gram stain score 7 to 8 or 9 to 10. Conclusion: Although bacterial vaginosis was associated with an increased risk of preterm birth, the gestational age at which bacterial vaginosis was screened for and diagnosed did not influence the increase.
AB - Objective: It is stated commonly that the earlier in pregnancy bacterial vaginosis is diagnosed, the greater is the increase in risk of preterm birth compared with women without bacterial vaginosis. However, this contention is based on small numbers of women. Study design: In this analysis of 12,937 women who were screened for bacterial vaginosis as part of a previously conducted clinical trial, the odds ratio of preterm birth (<7 weeks of gestation) for asymptomatic bacterial vaginosis-positive versus bacterial vaginosis-negative women was evaluated among women who were screened from 8 to 22 weeks of gestation. Results: The odds ratio of preterm birth among bacterial vaginosis-positive versus bacterial vaginosis-negative women ranged from 1.1 to 1.6 and did not vary significantly according to the gestational age at which bacterial vaginosis was screened. The odds ratio for preterm birth did not vary significantly by gestational age at diagnosis when bacterial vaginosis was subdivided into Gram stain score 7 to 8 or 9 to 10. Conclusion: Although bacterial vaginosis was associated with an increased risk of preterm birth, the gestational age at which bacterial vaginosis was screened for and diagnosed did not influence the increase.
KW - Bacterial vaginosis
KW - Gram stain
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=13444279044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444279044&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2004.07.017
DO - 10.1016/j.ajog.2004.07.017
M3 - Article
C2 - 15695989
AN - SCOPUS:13444279044
VL - 192
SP - 470
EP - 477
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -