Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation?

Mark A. Klebanoff, Sharon L. Hillier, Robert P. Nugent, Cora A. MacPherson, John C. Hauth, J. Christopher Carey, Margaret Harper, Ronald J. Wapner, Wayne Trout, Atef Moawad, Kenneth J. Leveno, Menachem Miodovnik, Baha M. Sibai, J. Peter VanDorsten, Mitchell P. Dombrowski, Mary J. O'Sullivan, Michael Varner, Oded Langer

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objective: It is stated commonly that the earlier in pregnancy bacterial vaginosis is diagnosed, the greater is the increase in risk of preterm birth compared with women without bacterial vaginosis. However, this contention is based on small numbers of women. Study design: In this analysis of 12,937 women who were screened for bacterial vaginosis as part of a previously conducted clinical trial, the odds ratio of preterm birth (<7 weeks of gestation) for asymptomatic bacterial vaginosis-positive versus bacterial vaginosis-negative women was evaluated among women who were screened from 8 to 22 weeks of gestation. Results: The odds ratio of preterm birth among bacterial vaginosis-positive versus bacterial vaginosis-negative women ranged from 1.1 to 1.6 and did not vary significantly according to the gestational age at which bacterial vaginosis was screened. The odds ratio for preterm birth did not vary significantly by gestational age at diagnosis when bacterial vaginosis was subdivided into Gram stain score 7 to 8 or 9 to 10. Conclusion: Although bacterial vaginosis was associated with an increased risk of preterm birth, the gestational age at which bacterial vaginosis was screened for and diagnosed did not influence the increase.

Original languageEnglish (US)
Pages (from-to)470-477
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume192
Issue number2
DOIs
StatePublished - Feb 2005

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Bacterial Vaginosis
Premature Birth
Pregnancy
Gestational Age
Odds Ratio
Clinical Trials

Keywords

  • Bacterial vaginosis
  • Gram stain
  • Preterm birth

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Klebanoff, M. A., Hillier, S. L., Nugent, R. P., MacPherson, C. A., Hauth, J. C., Carey, J. C., ... Langer, O. (2005). Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation? American Journal of Obstetrics and Gynecology, 192(2), 470-477. https://doi.org/10.1016/j.ajog.2004.07.017

Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation? / Klebanoff, Mark A.; Hillier, Sharon L.; Nugent, Robert P.; MacPherson, Cora A.; Hauth, John C.; Carey, J. Christopher; Harper, Margaret; Wapner, Ronald J.; Trout, Wayne; Moawad, Atef; Leveno, Kenneth J.; Miodovnik, Menachem; Sibai, Baha M.; VanDorsten, J. Peter; Dombrowski, Mitchell P.; O'Sullivan, Mary J.; Varner, Michael; Langer, Oded.

In: American Journal of Obstetrics and Gynecology, Vol. 192, No. 2, 02.2005, p. 470-477.

Research output: Contribution to journalArticle

Klebanoff, MA, Hillier, SL, Nugent, RP, MacPherson, CA, Hauth, JC, Carey, JC, Harper, M, Wapner, RJ, Trout, W, Moawad, A, Leveno, KJ, Miodovnik, M, Sibai, BM, VanDorsten, JP, Dombrowski, MP, O'Sullivan, MJ, Varner, M & Langer, O 2005, 'Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation?', American Journal of Obstetrics and Gynecology, vol. 192, no. 2, pp. 470-477. https://doi.org/10.1016/j.ajog.2004.07.017
Klebanoff, Mark A. ; Hillier, Sharon L. ; Nugent, Robert P. ; MacPherson, Cora A. ; Hauth, John C. ; Carey, J. Christopher ; Harper, Margaret ; Wapner, Ronald J. ; Trout, Wayne ; Moawad, Atef ; Leveno, Kenneth J. ; Miodovnik, Menachem ; Sibai, Baha M. ; VanDorsten, J. Peter ; Dombrowski, Mitchell P. ; O'Sullivan, Mary J. ; Varner, Michael ; Langer, Oded. / Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation?. In: American Journal of Obstetrics and Gynecology. 2005 ; Vol. 192, No. 2. pp. 470-477.
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abstract = "Objective: It is stated commonly that the earlier in pregnancy bacterial vaginosis is diagnosed, the greater is the increase in risk of preterm birth compared with women without bacterial vaginosis. However, this contention is based on small numbers of women. Study design: In this analysis of 12,937 women who were screened for bacterial vaginosis as part of a previously conducted clinical trial, the odds ratio of preterm birth (<7 weeks of gestation) for asymptomatic bacterial vaginosis-positive versus bacterial vaginosis-negative women was evaluated among women who were screened from 8 to 22 weeks of gestation. Results: The odds ratio of preterm birth among bacterial vaginosis-positive versus bacterial vaginosis-negative women ranged from 1.1 to 1.6 and did not vary significantly according to the gestational age at which bacterial vaginosis was screened. The odds ratio for preterm birth did not vary significantly by gestational age at diagnosis when bacterial vaginosis was subdivided into Gram stain score 7 to 8 or 9 to 10. Conclusion: Although bacterial vaginosis was associated with an increased risk of preterm birth, the gestational age at which bacterial vaginosis was screened for and diagnosed did not influence the increase.",
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