Is fibromuscular dysplasia underdiagnosed? A comparison of the prevalence of FMD seen in CORAL trial participants versus a single institution population of renal donor candidates

Nicholas J. Hendricks, Alan H. Matsumoto, John F. Angle, Aparna Baheti, Saher S. Sabri, Auh W. Park, James R. Stone, James T. Patrie, Lance Dworkin, Christopher J. Cooper, Timothy P. Murphy, Donald E. Cutlip

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Renal artery fibromuscular dysplasia (FMD) may be underdiagnosed. We evaluated the prevalence of FMD in CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) renal artery stent trial participants, in which FMD was an exclusion criterion for inclusion. We also evaluated the prevalence of FMD in a relatively healthy population of patients undergoing computed tomographic angiographic (CTA) screening for renal donor evaluation. All renal donor CTAs performed at our institution from January 2003 through November 2011 were retrospectively reviewed for the presence of FMD along with patient sex and age. These results were compared to angiographic core lab (ACL) findings for the CORAL trial. The CORAL ACL database contained 997 patients (mean age 69.3 years; 50% female). Fifty-eight (5.8%) CORAL trial patients (mean age 71.8 years; 75.9% female) demonstrated incidental FMD. The renal donor cohort included 220 patients (mean age 40.5 years; 64.5% female). Five (2.3%) demonstrated FMD (mean age 48.6 years; all female). The odds of FMD in the CORAL cohort were 2.65 times that seen in the renal donor cohort (95% CI: 1.12, 7.57). In conclusion, the 5.8% prevalence of renal artery FMD in the CORAL trial population, the presence of which was biased against, suggests underdiagnosis.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalVascular Medicine (United Kingdom)
Volume19
Issue number5
DOIs
StatePublished - Oct 11 2014
Externally publishedYes

Keywords

  • fibromuscular dysplasia
  • renal artery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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