Is hyperthermia teratogenic in the human?

B. B. Little, F. E. Ghali, L. M. Snell, K. A. Knoll, W. Johnston, L. C. Gilstrap

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Maternal hyperthermia during embryogenesis has been postulated to cause a variety of major congenital anomalies in exposed offspring. Although the literature regarding human exposures is not conclusive, studies using animal models support the contention that major structural anomalies may be produced. In the present study, pregnancy outcome of a cohort of women who reported having a temperature of 101°F or higher for 24 hours or more during the first trimester was compared to a control group of women (matched on last menstrual period, parity, and age) who denied having a fever. A statistically significant increased frequency of a specific type of congenital anomaly, abdominal wall defects, was found in offspring whose mothers had sustained high temperatures during embryogenesis. Although an increased risk of this type of congenital anomaly is not consistent with previous epidemiologic studies, similar defects of this organ system have been reported in offspring of pregnant nonhuman primates (monkeys) and rodents (guinea pigs) who experienced hyperthermia during pregnancy.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalAmerican Journal of Perinatology
Volume8
Issue number3
StatePublished - 1991

Fingerprint

Fever
Embryonic Development
Mothers
Temperature
Abdominal Wall
First Pregnancy Trimester
Pregnancy Outcome
Parity
Primates
Haplorhini
Epidemiologic Studies
Rodentia
Guinea Pigs
Animal Models
Pregnancy
Control Groups

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Little, B. B., Ghali, F. E., Snell, L. M., Knoll, K. A., Johnston, W., & Gilstrap, L. C. (1991). Is hyperthermia teratogenic in the human? American Journal of Perinatology, 8(3), 185-189.

Is hyperthermia teratogenic in the human? / Little, B. B.; Ghali, F. E.; Snell, L. M.; Knoll, K. A.; Johnston, W.; Gilstrap, L. C.

In: American Journal of Perinatology, Vol. 8, No. 3, 1991, p. 185-189.

Research output: Contribution to journalArticle

Little, BB, Ghali, FE, Snell, LM, Knoll, KA, Johnston, W & Gilstrap, LC 1991, 'Is hyperthermia teratogenic in the human?', American Journal of Perinatology, vol. 8, no. 3, pp. 185-189.
Little BB, Ghali FE, Snell LM, Knoll KA, Johnston W, Gilstrap LC. Is hyperthermia teratogenic in the human? American Journal of Perinatology. 1991;8(3):185-189.
Little, B. B. ; Ghali, F. E. ; Snell, L. M. ; Knoll, K. A. ; Johnston, W. ; Gilstrap, L. C. / Is hyperthermia teratogenic in the human?. In: American Journal of Perinatology. 1991 ; Vol. 8, No. 3. pp. 185-189.
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