Is postictal electrical silence a predictor of response to electroconvulsive therapy?

Trisha Suppes, Andrew Webb, Thomas Carmody, Eunice Gordon, Rolando Gutierrez-Esteinou, James I. Hudson, Harrison G. Pope

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Electroconvulsive therapy (ECT) is an established effective treatment modality for patients with severe depression. Recent studies have focused on developing predictors of response. In this prospective study, using percent decrease in Hamilton Depression Scale (21 items) as the outcome measure, we blindly evaluated 33 inpatiants with major depression to determine whether postictal suppression, the electrical silence following induced seizure,would predict treatment response to ECT. A significant relationship was observed between degree of postictal suppression and likelihood of clinical improvement. Postictal suppression should be explored in more controlled studies as a predictor of ECT response.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalJournal of affective disorders
Issue number1
StatePublished - Nov 4 1996


  • Affective illness
  • Electroconvulsive therapy
  • Major depression
  • Postictal suppression
  • Predictors
  • Treatment response

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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