Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?

Ana Luiza Gleisner, Lia Assumpcao, John L. Cameron, Christopher L. Wolfgang, Michael A. Choti, Joseph M. Herman, Richard D. Schulick, Timothy M. Pawlik

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Abstract

BACKGROUND. To date, no consensus has been reached regarding which primary tumor subtypes are managed appropriately with hepatic metastectomy. Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial. METHODS. Between 1995 and 2005, 1563 patients underwent surgical resection for periampullary carcinoma (n = 608 patients) or pancreatic adenocarcinoma (head, n = 905 patients; tail, n = 50 patients). Data on demographics, operative details, primary tumor status, and-when indicated-extent of hepatic metastasis were collected. RESULTS. Of the 1563 patients who underwent resection of periampullary or pancreatic adenocarcinoma, 22 patients (1.4%) underwent simultaneous hepatic resection for synchronous liver metastasis. The primary tumor site was ampullary (n = 1 patient), duodenal (n = 2 patients), distal bile duct (n = 2 patients), or pancreas (head, n = 10 patients; tail, n = 7 patients). The majority of patients (86.4%) had a solitary hepatic metastasis, and the median size of the largest lesion was 0.6 cm. Hepatic metastectomy included wedge resection (n = 20 patients), segmentectomy (n = 1 patient), and hemihepatectomy (n = 1 patient). After matching patients on primary tumor histology and location, the median survival of patients who underwent hepatic resection of synchronous metastasis was 5.9 months compared with 5.6 months for patients who underwent palliative bypass alone (P = .46) and 14.2 months for patients with no metastatic disease who underwent primary tumor resection only (P < .001). Pancreatic (median, 5.9 months) versus nonpancreatic (median, 9.9 months) primary tumor histology was not associated with a difference in survival in patients who underwent resection of synchronous liver metastasis (P = .43). CONCLUSIONS. Even in well selected patients with low-volume metastatic liver disease, simultaneous resection of periampullary or pancreatic carcinoma with synchronous liver metastases did not result in long-term survival in the overwhelming majority of patients.

Original languageEnglish (US)
Pages (from-to)2484-2492
Number of pages9
JournalCancer
Volume110
Issue number11
DOIs
StatePublished - Dec 1 2007

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Adenocarcinoma
Neoplasm Metastasis
Liver
Neoplasms
Survival
Histology
Head
Segmental Mastectomy
Bile Ducts

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gleisner, A. L., Assumpcao, L., Cameron, J. L., Wolfgang, C. L., Choti, M. A., Herman, J. M., ... Pawlik, T. M. (2007). Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? Cancer, 110(11), 2484-2492. https://doi.org/10.1002/cncr.23074

Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? / Gleisner, Ana Luiza; Assumpcao, Lia; Cameron, John L.; Wolfgang, Christopher L.; Choti, Michael A.; Herman, Joseph M.; Schulick, Richard D.; Pawlik, Timothy M.

In: Cancer, Vol. 110, No. 11, 01.12.2007, p. 2484-2492.

Research output: Contribution to journalArticle

Gleisner, AL, Assumpcao, L, Cameron, JL, Wolfgang, CL, Choti, MA, Herman, JM, Schulick, RD & Pawlik, TM 2007, 'Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?', Cancer, vol. 110, no. 11, pp. 2484-2492. https://doi.org/10.1002/cncr.23074
Gleisner AL, Assumpcao L, Cameron JL, Wolfgang CL, Choti MA, Herman JM et al. Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? Cancer. 2007 Dec 1;110(11):2484-2492. https://doi.org/10.1002/cncr.23074
Gleisner, Ana Luiza ; Assumpcao, Lia ; Cameron, John L. ; Wolfgang, Christopher L. ; Choti, Michael A. ; Herman, Joseph M. ; Schulick, Richard D. ; Pawlik, Timothy M. / Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?. In: Cancer. 2007 ; Vol. 110, No. 11. pp. 2484-2492.
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abstract = "BACKGROUND. To date, no consensus has been reached regarding which primary tumor subtypes are managed appropriately with hepatic metastectomy. Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial. METHODS. Between 1995 and 2005, 1563 patients underwent surgical resection for periampullary carcinoma (n = 608 patients) or pancreatic adenocarcinoma (head, n = 905 patients; tail, n = 50 patients). Data on demographics, operative details, primary tumor status, and-when indicated-extent of hepatic metastasis were collected. RESULTS. Of the 1563 patients who underwent resection of periampullary or pancreatic adenocarcinoma, 22 patients (1.4{\%}) underwent simultaneous hepatic resection for synchronous liver metastasis. The primary tumor site was ampullary (n = 1 patient), duodenal (n = 2 patients), distal bile duct (n = 2 patients), or pancreas (head, n = 10 patients; tail, n = 7 patients). The majority of patients (86.4{\%}) had a solitary hepatic metastasis, and the median size of the largest lesion was 0.6 cm. Hepatic metastectomy included wedge resection (n = 20 patients), segmentectomy (n = 1 patient), and hemihepatectomy (n = 1 patient). After matching patients on primary tumor histology and location, the median survival of patients who underwent hepatic resection of synchronous metastasis was 5.9 months compared with 5.6 months for patients who underwent palliative bypass alone (P = .46) and 14.2 months for patients with no metastatic disease who underwent primary tumor resection only (P < .001). Pancreatic (median, 5.9 months) versus nonpancreatic (median, 9.9 months) primary tumor histology was not associated with a difference in survival in patients who underwent resection of synchronous liver metastasis (P = .43). CONCLUSIONS. Even in well selected patients with low-volume metastatic liver disease, simultaneous resection of periampullary or pancreatic carcinoma with synchronous liver metastases did not result in long-term survival in the overwhelming majority of patients.",
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AU - Gleisner, Ana Luiza

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AU - Cameron, John L.

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AU - Choti, Michael A.

AU - Herman, Joseph M.

AU - Schulick, Richard D.

AU - Pawlik, Timothy M.

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N2 - BACKGROUND. To date, no consensus has been reached regarding which primary tumor subtypes are managed appropriately with hepatic metastectomy. Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial. METHODS. Between 1995 and 2005, 1563 patients underwent surgical resection for periampullary carcinoma (n = 608 patients) or pancreatic adenocarcinoma (head, n = 905 patients; tail, n = 50 patients). Data on demographics, operative details, primary tumor status, and-when indicated-extent of hepatic metastasis were collected. RESULTS. Of the 1563 patients who underwent resection of periampullary or pancreatic adenocarcinoma, 22 patients (1.4%) underwent simultaneous hepatic resection for synchronous liver metastasis. The primary tumor site was ampullary (n = 1 patient), duodenal (n = 2 patients), distal bile duct (n = 2 patients), or pancreas (head, n = 10 patients; tail, n = 7 patients). The majority of patients (86.4%) had a solitary hepatic metastasis, and the median size of the largest lesion was 0.6 cm. Hepatic metastectomy included wedge resection (n = 20 patients), segmentectomy (n = 1 patient), and hemihepatectomy (n = 1 patient). After matching patients on primary tumor histology and location, the median survival of patients who underwent hepatic resection of synchronous metastasis was 5.9 months compared with 5.6 months for patients who underwent palliative bypass alone (P = .46) and 14.2 months for patients with no metastatic disease who underwent primary tumor resection only (P < .001). Pancreatic (median, 5.9 months) versus nonpancreatic (median, 9.9 months) primary tumor histology was not associated with a difference in survival in patients who underwent resection of synchronous liver metastasis (P = .43). CONCLUSIONS. Even in well selected patients with low-volume metastatic liver disease, simultaneous resection of periampullary or pancreatic carcinoma with synchronous liver metastases did not result in long-term survival in the overwhelming majority of patients.

AB - BACKGROUND. To date, no consensus has been reached regarding which primary tumor subtypes are managed appropriately with hepatic metastectomy. Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial. METHODS. Between 1995 and 2005, 1563 patients underwent surgical resection for periampullary carcinoma (n = 608 patients) or pancreatic adenocarcinoma (head, n = 905 patients; tail, n = 50 patients). Data on demographics, operative details, primary tumor status, and-when indicated-extent of hepatic metastasis were collected. RESULTS. Of the 1563 patients who underwent resection of periampullary or pancreatic adenocarcinoma, 22 patients (1.4%) underwent simultaneous hepatic resection for synchronous liver metastasis. The primary tumor site was ampullary (n = 1 patient), duodenal (n = 2 patients), distal bile duct (n = 2 patients), or pancreas (head, n = 10 patients; tail, n = 7 patients). The majority of patients (86.4%) had a solitary hepatic metastasis, and the median size of the largest lesion was 0.6 cm. Hepatic metastectomy included wedge resection (n = 20 patients), segmentectomy (n = 1 patient), and hemihepatectomy (n = 1 patient). After matching patients on primary tumor histology and location, the median survival of patients who underwent hepatic resection of synchronous metastasis was 5.9 months compared with 5.6 months for patients who underwent palliative bypass alone (P = .46) and 14.2 months for patients with no metastatic disease who underwent primary tumor resection only (P < .001). Pancreatic (median, 5.9 months) versus nonpancreatic (median, 9.9 months) primary tumor histology was not associated with a difference in survival in patients who underwent resection of synchronous liver metastasis (P = .43). CONCLUSIONS. Even in well selected patients with low-volume metastatic liver disease, simultaneous resection of periampullary or pancreatic carcinoma with synchronous liver metastases did not result in long-term survival in the overwhelming majority of patients.

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