Is there an association between coronary atherosclerosis and carcinoma of the prostate in men aged 50 years and older? An autopsy and coroner based post-mortem study

B. I. Omalu, J. L. Hammers, A. V. Parwani, J. Balani, A. Shakir, R. B. Ness

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Atherosclerotic disease is the most common cause of death in the United States and prostate cancer has the highest incidence among males in the United States. Reports have indicated that atherosclerosis and cancers my share common pathoetiologic and pathogenetic cascades. If atherosclerosis and cancers have common pathoetiologic and pathogenetic cascades, both diseases will co-occur and patients may represent a potential target group for cancer screening interventions. Materials and Methods: Prostates and coronary vessels were examined from 37 deceased men, aged 50 years and older, who died unexpectedly and suddenly from traumatic causes. Tissue sections of the entire prostate were examined for benign and malignant lesions. Analysis of Variance was used to compare mean coronary artery atherosclerosis scores among groups of men with diagnosis of adenocarcinoma, intraepithelial neoplasm, benign hyperplasia and normal prostate glands. Results: Twelve prostates (32.5%) showed adenocarcinoma of the prostate, four with Gleason score 7 and eight with Gleason score 6. After adjustment for age and race, there remained no statistical difference between prostate pathology groups and atherosclerosis score (F = 0.72; P = 0.55). Conclusions: To our knowledge, ours is the first study to use direct pathological examination of tissues for definitive identification of atherosclerosis and prostate cancer. In our case series, the occurrence and progression of coronary atherosclerotic disease and cancer of the prostate were not associated.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalNigerian Journal of Clinical Practice
Volume16
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Coroners and Medical Examiners
Prostate
Coronary Artery Disease
Autopsy
Carcinoma
Atherosclerosis
Prostatic Neoplasms
Neoplasm Grading
Coronary Vessels
Adenocarcinoma
Carcinoma in Situ
Early Detection of Cancer
Hyperplasia
Coronary Disease
Cause of Death
Neoplasms
Analysis of Variance
Pathology
Incidence

Keywords

  • Atherosclerotic cardiovascular disease
  • Pathology
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Is there an association between coronary atherosclerosis and carcinoma of the prostate in men aged 50 years and older? An autopsy and coroner based post-mortem study. / Omalu, B. I.; Hammers, J. L.; Parwani, A. V.; Balani, J.; Shakir, A.; Ness, R. B.

In: Nigerian Journal of Clinical Practice, Vol. 16, No. 1, 01.2013, p. 45-48.

Research output: Contribution to journalArticle

@article{9462971791624e6092bd521fc5f3a6dd,
title = "Is there an association between coronary atherosclerosis and carcinoma of the prostate in men aged 50 years and older? An autopsy and coroner based post-mortem study",
abstract = "Background: Atherosclerotic disease is the most common cause of death in the United States and prostate cancer has the highest incidence among males in the United States. Reports have indicated that atherosclerosis and cancers my share common pathoetiologic and pathogenetic cascades. If atherosclerosis and cancers have common pathoetiologic and pathogenetic cascades, both diseases will co-occur and patients may represent a potential target group for cancer screening interventions. Materials and Methods: Prostates and coronary vessels were examined from 37 deceased men, aged 50 years and older, who died unexpectedly and suddenly from traumatic causes. Tissue sections of the entire prostate were examined for benign and malignant lesions. Analysis of Variance was used to compare mean coronary artery atherosclerosis scores among groups of men with diagnosis of adenocarcinoma, intraepithelial neoplasm, benign hyperplasia and normal prostate glands. Results: Twelve prostates (32.5{\%}) showed adenocarcinoma of the prostate, four with Gleason score 7 and eight with Gleason score 6. After adjustment for age and race, there remained no statistical difference between prostate pathology groups and atherosclerosis score (F = 0.72; P = 0.55). Conclusions: To our knowledge, ours is the first study to use direct pathological examination of tissues for definitive identification of atherosclerosis and prostate cancer. In our case series, the occurrence and progression of coronary atherosclerotic disease and cancer of the prostate were not associated.",
keywords = "Atherosclerotic cardiovascular disease, Pathology, Prostate cancer",
author = "Omalu, {B. I.} and Hammers, {J. L.} and Parwani, {A. V.} and J. Balani and A. Shakir and Ness, {R. B.}",
year = "2013",
month = "1",
doi = "10.4103/1119-3077.106741",
language = "English (US)",
volume = "16",
pages = "45--48",
journal = "Nigerian Journal of Clinical Practice",
issn = "1119-3077",
publisher = "Medical and Dental Consultants Association of Nigeria (MDCAN)",
number = "1",

}

TY - JOUR

T1 - Is there an association between coronary atherosclerosis and carcinoma of the prostate in men aged 50 years and older? An autopsy and coroner based post-mortem study

AU - Omalu, B. I.

AU - Hammers, J. L.

AU - Parwani, A. V.

AU - Balani, J.

AU - Shakir, A.

AU - Ness, R. B.

PY - 2013/1

Y1 - 2013/1

N2 - Background: Atherosclerotic disease is the most common cause of death in the United States and prostate cancer has the highest incidence among males in the United States. Reports have indicated that atherosclerosis and cancers my share common pathoetiologic and pathogenetic cascades. If atherosclerosis and cancers have common pathoetiologic and pathogenetic cascades, both diseases will co-occur and patients may represent a potential target group for cancer screening interventions. Materials and Methods: Prostates and coronary vessels were examined from 37 deceased men, aged 50 years and older, who died unexpectedly and suddenly from traumatic causes. Tissue sections of the entire prostate were examined for benign and malignant lesions. Analysis of Variance was used to compare mean coronary artery atherosclerosis scores among groups of men with diagnosis of adenocarcinoma, intraepithelial neoplasm, benign hyperplasia and normal prostate glands. Results: Twelve prostates (32.5%) showed adenocarcinoma of the prostate, four with Gleason score 7 and eight with Gleason score 6. After adjustment for age and race, there remained no statistical difference between prostate pathology groups and atherosclerosis score (F = 0.72; P = 0.55). Conclusions: To our knowledge, ours is the first study to use direct pathological examination of tissues for definitive identification of atherosclerosis and prostate cancer. In our case series, the occurrence and progression of coronary atherosclerotic disease and cancer of the prostate were not associated.

AB - Background: Atherosclerotic disease is the most common cause of death in the United States and prostate cancer has the highest incidence among males in the United States. Reports have indicated that atherosclerosis and cancers my share common pathoetiologic and pathogenetic cascades. If atherosclerosis and cancers have common pathoetiologic and pathogenetic cascades, both diseases will co-occur and patients may represent a potential target group for cancer screening interventions. Materials and Methods: Prostates and coronary vessels were examined from 37 deceased men, aged 50 years and older, who died unexpectedly and suddenly from traumatic causes. Tissue sections of the entire prostate were examined for benign and malignant lesions. Analysis of Variance was used to compare mean coronary artery atherosclerosis scores among groups of men with diagnosis of adenocarcinoma, intraepithelial neoplasm, benign hyperplasia and normal prostate glands. Results: Twelve prostates (32.5%) showed adenocarcinoma of the prostate, four with Gleason score 7 and eight with Gleason score 6. After adjustment for age and race, there remained no statistical difference between prostate pathology groups and atherosclerosis score (F = 0.72; P = 0.55). Conclusions: To our knowledge, ours is the first study to use direct pathological examination of tissues for definitive identification of atherosclerosis and prostate cancer. In our case series, the occurrence and progression of coronary atherosclerotic disease and cancer of the prostate were not associated.

KW - Atherosclerotic cardiovascular disease

KW - Pathology

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=84873685749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873685749&partnerID=8YFLogxK

U2 - 10.4103/1119-3077.106741

DO - 10.4103/1119-3077.106741

M3 - Article

C2 - 23377469

AN - SCOPUS:84873685749

VL - 16

SP - 45

EP - 48

JO - Nigerian Journal of Clinical Practice

JF - Nigerian Journal of Clinical Practice

SN - 1119-3077

IS - 1

ER -