Is there still a role for high-frequency oscillatory ventilation in neonates, children and adults?

Susan R. Hupp, David A. Turner, Kyle J. Rehder

Research output: Contribution to journalReview article

5 Scopus citations


Critically ill patients with respiratory pathology often require mechanical ventilation and while low tidal volume ventilation has become the mainstay of treatment, achieving adequate gas exchange may not be attainable with conventional ventilator modalities. In attempt to achieve gas exchange goals and also mitigate lung injury, high frequency ventilation is often implemented which couples low tidal volumes with sustained mean airway pressure. This manuscript presents the physiology of high-frequency oscillatory ventilation, reviews the currently available data on its use and provides strategies and approaches for this mode of ventilation.

Original languageEnglish (US)
Pages (from-to)603-618
Number of pages16
JournalExpert Review of Respiratory Medicine
Issue number5
StatePublished - Jan 1 2015



  • Acute respiratory distress syndrome
  • High frequency
  • High-frequency oscillatory ventilation
  • Mechanical ventilation
  • Pediatric
  • Ventilator-induced lung injury

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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