Island cells control temporal association memory

Takashi Kitamura, Michele Pignatelli, Junghyup Suh, Keigo Kohara, Atsushi Yoshiki, Kuniya Abe, Susumu Tonegawa

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory.

Original languageEnglish (US)
Pages (from-to)896-901
Number of pages6
JournalScience
Volume343
Issue number6173
DOIs
StatePublished - Jan 1 2014

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Islands
Entorhinal Cortex
Hippocampal CA1 Region
Episodic Memory
Pyramidal Cells
Interneurons
Dendrites
Fear
Neurons

ASJC Scopus subject areas

  • General

Cite this

Kitamura, T., Pignatelli, M., Suh, J., Kohara, K., Yoshiki, A., Abe, K., & Tonegawa, S. (2014). Island cells control temporal association memory. Science, 343(6173), 896-901. https://doi.org/10.1126/science.1244634

Island cells control temporal association memory. / Kitamura, Takashi; Pignatelli, Michele; Suh, Junghyup; Kohara, Keigo; Yoshiki, Atsushi; Abe, Kuniya; Tonegawa, Susumu.

In: Science, Vol. 343, No. 6173, 01.01.2014, p. 896-901.

Research output: Contribution to journalArticle

Kitamura, T, Pignatelli, M, Suh, J, Kohara, K, Yoshiki, A, Abe, K & Tonegawa, S 2014, 'Island cells control temporal association memory', Science, vol. 343, no. 6173, pp. 896-901. https://doi.org/10.1126/science.1244634
Kitamura T, Pignatelli M, Suh J, Kohara K, Yoshiki A, Abe K et al. Island cells control temporal association memory. Science. 2014 Jan 1;343(6173):896-901. https://doi.org/10.1126/science.1244634
Kitamura, Takashi ; Pignatelli, Michele ; Suh, Junghyup ; Kohara, Keigo ; Yoshiki, Atsushi ; Abe, Kuniya ; Tonegawa, Susumu. / Island cells control temporal association memory. In: Science. 2014 ; Vol. 343, No. 6173. pp. 896-901.
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