Abstract
Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 896-901 |
| Number of pages | 6 |
| Journal | Science |
| Volume | 343 |
| Issue number | 6173 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Island cells control temporal association memory. / Kitamura, Takashi; Pignatelli, Michele; Suh, Junghyup; Kohara, Keigo; Yoshiki, Atsushi; Abe, Kuniya; Tonegawa, Susumu.
In: Science, Vol. 343, No. 6173, 01.01.2014, p. 896-901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Island cells control temporal association memory
AU - Kitamura, Takashi
AU - Pignatelli, Michele
AU - Suh, Junghyup
AU - Kohara, Keigo
AU - Yoshiki, Atsushi
AU - Abe, Kuniya
AU - Tonegawa, Susumu
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory.
AB - Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory.
UR - http://www.scopus.com/inward/record.url?scp=84894254839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894254839&partnerID=8YFLogxK
U2 - 10.1126/science.1244634
DO - 10.1126/science.1244634
M3 - Article
C2 - 24457215
AN - SCOPUS:84894254839
VL - 343
SP - 896
EP - 901
JO - Science
JF - Science
SN - 0036-8075
IS - 6173
ER -