TY - JOUR
T1 - Islet-cell abnormalities in non-insulin-dependent diabetes mellitus
AU - Raskin, Philip
PY - 1985/8/23
Y1 - 1985/8/23
N2 - Patients with non-insulin-dependent diabetes mellitus have enlarged islets of Langerhans, an increased number of insulin-secreting beta cells, and a "horseshoe-shaped" relationship between plasma insulin and glucose levels. To some extent, beta-cell dysfunction in patients with type II diabetes is reversible with appropriate hypoglycemic therapy. Defects in the glucagon-secreting alpha cells in patients with non-insulin-dependent diabetes mellitus include basal hyperglucagonemia, an exaggerated glucagon response to aminogenic stimuli, and hyposuppressibility of glucagon by hyperglycemia. Although peripheral resistance to insulin may play a role in type II diabetes, defects in islet-cell function clearly play a significant role as well.
AB - Patients with non-insulin-dependent diabetes mellitus have enlarged islets of Langerhans, an increased number of insulin-secreting beta cells, and a "horseshoe-shaped" relationship between plasma insulin and glucose levels. To some extent, beta-cell dysfunction in patients with type II diabetes is reversible with appropriate hypoglycemic therapy. Defects in the glucagon-secreting alpha cells in patients with non-insulin-dependent diabetes mellitus include basal hyperglucagonemia, an exaggerated glucagon response to aminogenic stimuli, and hyposuppressibility of glucagon by hyperglycemia. Although peripheral resistance to insulin may play a role in type II diabetes, defects in islet-cell function clearly play a significant role as well.
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U2 - 10.1016/0002-9343(85)90578-9
DO - 10.1016/0002-9343(85)90578-9
M3 - Article
C2 - 3898829
AN - SCOPUS:0022245502
SN - 0002-9343
VL - 79
SP - 2
EP - 5
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 2 SUPPL. 2
ER -