Hypoxia-inducible factor-1 (HIF-1) is a key regulator of erythropoiesis. In this article, we report 3 novel mutations, P378S, A385T, and G206C, on the EGLN1 gene encoding the negative HIF-1α regulator prolyl hydroxylase domain-2 (PHD2) in 3 patients with isolated erythrocytosis. These mutations impair PHD2 protein stability and partially reduce PHD2 activity, leading to increased HIF-1α protein levels in cultured cells.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine High Impact Case Reports|
|State||Published - 2020|
ASJC Scopus subject areas
- Safety, Risk, Reliability and Quality
- Safety Research