Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells

Eric Schaeffer, Dean Smith, Graeme Mardon, William Quinn, Charles Zuker

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

We have isolated and characterized two new protein kinase C (PKC) genes from D. melanogaster. One, dPKC98F, maps to chromosome region 98F and displays over 60% amino acid sequence identity with members of a recently described "PKC-related" subfamily in mammals. The other, dPKC53E(ey), maps to region 53E 4-7 on the second chromosome and lies within 50 kb of a PKC gene previously characterized (dPKC). While dPKC98F transcripts are expressed throughout development, expression of the two genes mapping at cytogenetic location 53E is primarily in adults. dPKC98F and the previously reported 53E gene are transcribed predominantly in brain tissue. In contrast, dPKC53E(ey) is transcribed only in photoreceptor cells. We will discuss the significance of this tissue-specific localization with regard to phototransduction.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalCell
Volume57
Issue number3
DOIs
StatePublished - May 5 1989

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Drosophila Proteins
Photoreceptor Cells
Protein Kinase C
Genes
Chromosomes
Light Signal Transduction
Chromosome Mapping
Tissue
Cytogenetics
Mammals
Amino Acid Sequence
Brain
Display devices
Amino Acids

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. / Schaeffer, Eric; Smith, Dean; Mardon, Graeme; Quinn, William; Zuker, Charles.

In: Cell, Vol. 57, No. 3, 05.05.1989, p. 403-412.

Research output: Contribution to journalArticle

Schaeffer, Eric ; Smith, Dean ; Mardon, Graeme ; Quinn, William ; Zuker, Charles. / Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. In: Cell. 1989 ; Vol. 57, No. 3. pp. 403-412.
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