TY - JOUR
T1 - Isolation of an ftsZ homolog from the archaebacterium Halobacterium salinarium
T2 - Implications for the evolution of FtsZ and tubulin
AU - Margolin, William
AU - Wang, Richard
AU - Kumar, Madhu
PY - 1996/3
Y1 - 1996/3
N2 - We have isolated a homolog of the cell division gene ftsZ from the extremely halophilic archaebacterium Halobacterium salinarium. The predicted protein of 39 kDa is divergent relative to eubacterial homologs, with 32% identity to Escherichia coli FtsZ. No other eubacterial cell division gene homologs were found adjacent to H. salinarium ftsZ. Expression of the ftsZ gene region in H. salinarium induced significant morphological changes leading to the loss of rod shape. Phylogenetic analysis demonstrated that the H. salinarium FtsZ protein is more related to tubulins than are the FtsZ proteins of eubacteria, supporting the hypothesis that FtsZ may have evolved into eukaryotic tubulin.
AB - We have isolated a homolog of the cell division gene ftsZ from the extremely halophilic archaebacterium Halobacterium salinarium. The predicted protein of 39 kDa is divergent relative to eubacterial homologs, with 32% identity to Escherichia coli FtsZ. No other eubacterial cell division gene homologs were found adjacent to H. salinarium ftsZ. Expression of the ftsZ gene region in H. salinarium induced significant morphological changes leading to the loss of rod shape. Phylogenetic analysis demonstrated that the H. salinarium FtsZ protein is more related to tubulins than are the FtsZ proteins of eubacteria, supporting the hypothesis that FtsZ may have evolved into eukaryotic tubulin.
UR - http://www.scopus.com/inward/record.url?scp=0029864056&partnerID=8YFLogxK
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U2 - 10.1128/jb.178.5.1320-1327.1996
DO - 10.1128/jb.178.5.1320-1327.1996
M3 - Article
C2 - 8631708
AN - SCOPUS:0029864056
SN - 0021-9193
VL - 178
SP - 1320
EP - 1327
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 5
ER -