Isoniazid in autoimmunity: A trigger for multiple sclerosis?

Bardia Nourbakhsh, Olaf Stüve

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Isoniazid (INH) is a prodrug activated by the mycobacterial enzyme KatG, a multifunctional catalase peroxidase. KatG converts INH to reactive antimycobacterial species. For decades, an association between INH and drug-induced lupus erythematosus has been recognized. We present the case of a patient with primary progressive multiple sclerosis whose disease commenced weeks after initiating INH therapy for prevention of tuberculosis. Possible mechanisms by which INH may trigger autoimmunity in humans are discussed.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalTherapeutic Advances in Neurological Disorders
Volume7
Issue number5
DOIs
StatePublished - Sep 2014

Keywords

  • Autoimmunity
  • Isoniazid
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology

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