Isovolemic hemodilution-red cell exchange for prevention of cerebrovascular accident in sickle cell anemia: The standard operating procedure

Karén Matevosyan, Christina Anderson, Ravi Sarode

Research output: Contribution to journalReview article

11 Scopus citations


Red blood cell exchange is an accepted superior therapy to simple chronic transfusion, due to minimal risk of iron overload, for secondary prevention of cerebrovascular accidents in selected patients with sickle cell anemia. Recently, we described our experience of Isovolemic Hemodilution-Red Blood Cell Exchange (IHD-RBCx), a two-step modification of the conventional RBCx with several advantages, including cost reduction. We are describing our standard operating procedure for IHD-RBCx with COBE Spectra apheresis system to make it widely available to the apheresis centers interested in implementing this procedure. J. Clin. Apheresis, 2012.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalJournal of Clinical Apheresis
Issue number2
StatePublished - Feb 3 2012



  • COBE spectra
  • FCR
  • hematocrit
  • hemoglobin S
  • stroke prevention

ASJC Scopus subject areas

  • Hematology

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