Ivabradine Overdose in a Newborn: Precautions of Dispensing in Infants

Pezad Doctor, William A. Scott, Kaitlin Tindel, Hoang H. Nguyen

Research output: Contribution to journalArticlepeer-review

Abstract

Ivabradine is currently approved to reduce heart rate in children with chronic heart failure and dilated cardiomyopathy. Ivabradine has also been used off-label in children to treat automatic tachyarrhythmias such as ectopic atrial tachycardia and junctional ectopic tachycardia. Adverse effects of ivabradine at physiological doses as well as its toxicity at supra-physiological doses have rarely been reported in adults. In children, weight-based dosing requires dilution of commercially available ivabradine oral solution for accuracy. We describe a case of ivabradine overdose in a newborn (treated for ectopic atrial tachycardia) secondary to inaccurate dosing leading to the infant receiving 10 times more drug than prescribed.

Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
JournalCardiology Research
Volume13
Issue number4
DOIs
StatePublished - Aug 2022
Externally publishedYes

Keywords

  • Ectopic atrial tachycardia
  • Ivabradine toxicity
  • Newborn
  • Sinus bradycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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