Jejunal and ileal malabsorption of calcium in patients with chronic renal disease on hemodialysis: correction of the defect by 1α hydroxy vitamin D (1α HCC)

P. Vergne Marini, C. Y C Pak, T. F. Parker

Research output: Contribution to journalArticle

Abstract

Calcium absorption in renal failure is markedly impaired, and is associated with a deficiency in 1,25 dihydrocholecalciferol (1,25 DHCC). Previous' absorption studies on the effect of 1,25 DHCC or 1α HCC were done by the radioactive calcium test meal which reflects isotopic and not necessarily net calcium absorption, did not define the mechanisms of absorption or the site within the GI tract from which absorption takes place. The purpose of the experiments was to study the effects of one week of therapy with 2 μg of 1α HCC orally per day in correcting calcium malabsorption by using the segmental perfusion technique. Fifteen patients (8 jejunals, 7 ileals) were perfused for 1.75 hr before and after 1α HCC with calcium gluconate solutions of 0, 1, 5, 10, 15 or 20 mM/l which also contained 50 mM/l NaCl, 5 mM/l KCl, and polyethylene glycol 0.5%. The results showed: in the jejunum 1α HCC caused the average calcium absorption rates to increase at all 4 luminal concentrations, (p<.005); in the jejunum the control studies at 1 mM/l showed calcium movement from blood to lumen (secretion) whereas treatment with 1α HCC revealed movement from lumen to blood (absorption); calcium absorption in the ileum was markedly depressed at all concentrations and 1α HCC increased the average absorption rates (p 0.0001 to < 0.025 for the 5 to 20 mM/l solutions). Calcium absorption in both segments is markedly depressed in patients with renal failure. The defect is corrected by 1α HCC, which in addition to absorption against electrochemical gradient, points to an active transport system in both segments in humans.

Original languageEnglish (US)
JournalClinical Research
Volume23
Issue number3
StatePublished - 1975

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Chronic Renal Insufficiency
Vitamin D
Renal Dialysis
Calcium
Defects
Blood
Jejunum
Calcium Gluconate
Renal Insufficiency
Active Biological Transport
Ileum
Meals
Gastrointestinal Tract
Perfusion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Jejunal and ileal malabsorption of calcium in patients with chronic renal disease on hemodialysis: correction of the defect by 1α hydroxy vitamin D (1α HCC)",
abstract = "Calcium absorption in renal failure is markedly impaired, and is associated with a deficiency in 1,25 dihydrocholecalciferol (1,25 DHCC). Previous' absorption studies on the effect of 1,25 DHCC or 1α HCC were done by the radioactive calcium test meal which reflects isotopic and not necessarily net calcium absorption, did not define the mechanisms of absorption or the site within the GI tract from which absorption takes place. The purpose of the experiments was to study the effects of one week of therapy with 2 μg of 1α HCC orally per day in correcting calcium malabsorption by using the segmental perfusion technique. Fifteen patients (8 jejunals, 7 ileals) were perfused for 1.75 hr before and after 1α HCC with calcium gluconate solutions of 0, 1, 5, 10, 15 or 20 mM/l which also contained 50 mM/l NaCl, 5 mM/l KCl, and polyethylene glycol 0.5{\%}. The results showed: in the jejunum 1α HCC caused the average calcium absorption rates to increase at all 4 luminal concentrations, (p<.005); in the jejunum the control studies at 1 mM/l showed calcium movement from blood to lumen (secretion) whereas treatment with 1α HCC revealed movement from lumen to blood (absorption); calcium absorption in the ileum was markedly depressed at all concentrations and 1α HCC increased the average absorption rates (p 0.0001 to < 0.025 for the 5 to 20 mM/l solutions). Calcium absorption in both segments is markedly depressed in patients with renal failure. The defect is corrected by 1α HCC, which in addition to absorption against electrochemical gradient, points to an active transport system in both segments in humans.",
author = "{Vergne Marini}, P. and Pak, {C. Y C} and Parker, {T. F.}",
year = "1975",
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T1 - Jejunal and ileal malabsorption of calcium in patients with chronic renal disease on hemodialysis

T2 - correction of the defect by 1α hydroxy vitamin D (1α HCC)

AU - Vergne Marini, P.

AU - Pak, C. Y C

AU - Parker, T. F.

PY - 1975

Y1 - 1975

N2 - Calcium absorption in renal failure is markedly impaired, and is associated with a deficiency in 1,25 dihydrocholecalciferol (1,25 DHCC). Previous' absorption studies on the effect of 1,25 DHCC or 1α HCC were done by the radioactive calcium test meal which reflects isotopic and not necessarily net calcium absorption, did not define the mechanisms of absorption or the site within the GI tract from which absorption takes place. The purpose of the experiments was to study the effects of one week of therapy with 2 μg of 1α HCC orally per day in correcting calcium malabsorption by using the segmental perfusion technique. Fifteen patients (8 jejunals, 7 ileals) were perfused for 1.75 hr before and after 1α HCC with calcium gluconate solutions of 0, 1, 5, 10, 15 or 20 mM/l which also contained 50 mM/l NaCl, 5 mM/l KCl, and polyethylene glycol 0.5%. The results showed: in the jejunum 1α HCC caused the average calcium absorption rates to increase at all 4 luminal concentrations, (p<.005); in the jejunum the control studies at 1 mM/l showed calcium movement from blood to lumen (secretion) whereas treatment with 1α HCC revealed movement from lumen to blood (absorption); calcium absorption in the ileum was markedly depressed at all concentrations and 1α HCC increased the average absorption rates (p 0.0001 to < 0.025 for the 5 to 20 mM/l solutions). Calcium absorption in both segments is markedly depressed in patients with renal failure. The defect is corrected by 1α HCC, which in addition to absorption against electrochemical gradient, points to an active transport system in both segments in humans.

AB - Calcium absorption in renal failure is markedly impaired, and is associated with a deficiency in 1,25 dihydrocholecalciferol (1,25 DHCC). Previous' absorption studies on the effect of 1,25 DHCC or 1α HCC were done by the radioactive calcium test meal which reflects isotopic and not necessarily net calcium absorption, did not define the mechanisms of absorption or the site within the GI tract from which absorption takes place. The purpose of the experiments was to study the effects of one week of therapy with 2 μg of 1α HCC orally per day in correcting calcium malabsorption by using the segmental perfusion technique. Fifteen patients (8 jejunals, 7 ileals) were perfused for 1.75 hr before and after 1α HCC with calcium gluconate solutions of 0, 1, 5, 10, 15 or 20 mM/l which also contained 50 mM/l NaCl, 5 mM/l KCl, and polyethylene glycol 0.5%. The results showed: in the jejunum 1α HCC caused the average calcium absorption rates to increase at all 4 luminal concentrations, (p<.005); in the jejunum the control studies at 1 mM/l showed calcium movement from blood to lumen (secretion) whereas treatment with 1α HCC revealed movement from lumen to blood (absorption); calcium absorption in the ileum was markedly depressed at all concentrations and 1α HCC increased the average absorption rates (p 0.0001 to < 0.025 for the 5 to 20 mM/l solutions). Calcium absorption in both segments is markedly depressed in patients with renal failure. The defect is corrected by 1α HCC, which in addition to absorption against electrochemical gradient, points to an active transport system in both segments in humans.

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