JmjC domain proteins modulate circadian behaviors and sleep in Drosophila

Nevine A. Shalaby, Jorge H. Pinzon, Anjana S. Narayanan, Eugene Jennifer Jin, Morgan P. Ritz, Rachel J. Dove, Heike Wolfenberg, Aylin R. Rodan, Michael Buszczak, Adrian Rothenfluh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Jumonji (JmjC) domain proteins are known regulators of gene expression and chromatin organization by way of histone demethylation. Chromatin modification and remodeling provides a means to modulate the activity of large numbers of genes, but the importance of this class of predicted histone-modifying enzymes for different aspects of post-developmental processes remains poorly understood. Here we test the function of all 11 non-lethal members in the regulation of circadian rhythms and sleep. We find loss of every Drosophila JmjC gene affects different aspects of circadian behavior and sleep in a specific manner. Together these findings suggest that the majority of JmjC proteins function as regulators of behavior, rather than controlling essential developmental programs.

Original languageEnglish (US)
Article number815
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Histones
Drosophila
Sleep
Chromatin Assembly and Disassembly
Regulator Genes
Circadian Rhythm
Genes
Chromatin
Gene Expression
Enzymes
Proteins
Protein Domains

ASJC Scopus subject areas

  • General

Cite this

Shalaby, N. A., Pinzon, J. H., Narayanan, A. S., Jin, E. J., Ritz, M. P., Dove, R. J., ... Rothenfluh, A. (2018). JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Scientific Reports, 8(1), [815]. https://doi.org/10.1038/s41598-017-18989-1

JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. / Shalaby, Nevine A.; Pinzon, Jorge H.; Narayanan, Anjana S.; Jin, Eugene Jennifer; Ritz, Morgan P.; Dove, Rachel J.; Wolfenberg, Heike; Rodan, Aylin R.; Buszczak, Michael; Rothenfluh, Adrian.

In: Scientific Reports, Vol. 8, No. 1, 815, 01.12.2018.

Research output: Contribution to journalArticle

Shalaby NA, Pinzon JH, Narayanan AS, Jin EJ, Ritz MP, Dove RJ et al. JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Scientific Reports. 2018 Dec 1;8(1). 815. https://doi.org/10.1038/s41598-017-18989-1
Shalaby, Nevine A. ; Pinzon, Jorge H. ; Narayanan, Anjana S. ; Jin, Eugene Jennifer ; Ritz, Morgan P. ; Dove, Rachel J. ; Wolfenberg, Heike ; Rodan, Aylin R. ; Buszczak, Michael ; Rothenfluh, Adrian. / JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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