JmjC domain proteins modulate circadian behaviors and sleep in Drosophila

Nevine A. Shalaby, Jorge H. Pinzon, Anjana S. Narayanan, Eugene Jennifer Jin, Morgan P. Ritz, Rachel J. Dove, Heike Wolfenberg, Aylin R. Rodan, Michael Buszczak, Adrian Rothenfluh

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7 Scopus citations


Jumonji (JmjC) domain proteins are known regulators of gene expression and chromatin organization by way of histone demethylation. Chromatin modification and remodeling provides a means to modulate the activity of large numbers of genes, but the importance of this class of predicted histone-modifying enzymes for different aspects of post-developmental processes remains poorly understood. Here we test the function of all 11 non-lethal members in the regulation of circadian rhythms and sleep. We find loss of every Drosophila JmjC gene affects different aspects of circadian behavior and sleep in a specific manner. Together these findings suggest that the majority of JmjC proteins function as regulators of behavior, rather than controlling essential developmental programs.

Original languageEnglish (US)
Article number815
JournalScientific Reports
Issue number1
StatePublished - Dec 1 2018


ASJC Scopus subject areas

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Cite this

Shalaby, N. A., Pinzon, J. H., Narayanan, A. S., Jin, E. J., Ritz, M. P., Dove, R. J., Wolfenberg, H., Rodan, A. R., Buszczak, M., & Rothenfluh, A. (2018). JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Scientific Reports, 8(1), [815].