Junctional epidermolysis bullosa. Treatment with phenytoin

M. F. Guill, B. B. Wray, R. B. Rogers, K. B. Yancey, B. S. Allen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Junctional epidermolysis bullosa (EB) is a rare, heritable, blistering disease of the skin characterized by presence of bullae at birth, lack of scarring of the lesions, and early death. To date there has been no effective treatment for the disease. Phenytoin, which decreases collagenase activity in human skin explants and fibroblast cultures, has been used successfully to treat patients with recessive dystrophic EB. We found a marked decrease in new blister formation in one child with junctional EB during phenytoin therapy.

Original languageEnglish (US)
Pages (from-to)992-994
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume137
Issue number10
StatePublished - 1983

Fingerprint

Junctional Epidermolysis Bullosa
Phenytoin
Blister
Epidermolysis Bullosa Dystrophica
Collagenases
Skin Diseases
Human Activities
Cicatrix
Fibroblasts
Parturition
Skin
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Guill, M. F., Wray, B. B., Rogers, R. B., Yancey, K. B., & Allen, B. S. (1983). Junctional epidermolysis bullosa. Treatment with phenytoin. American Journal of Diseases of Children, 137(10), 992-994.

Junctional epidermolysis bullosa. Treatment with phenytoin. / Guill, M. F.; Wray, B. B.; Rogers, R. B.; Yancey, K. B.; Allen, B. S.

In: American Journal of Diseases of Children, Vol. 137, No. 10, 1983, p. 992-994.

Research output: Contribution to journalArticle

Guill, MF, Wray, BB, Rogers, RB, Yancey, KB & Allen, BS 1983, 'Junctional epidermolysis bullosa. Treatment with phenytoin', American Journal of Diseases of Children, vol. 137, no. 10, pp. 992-994.
Guill, M. F. ; Wray, B. B. ; Rogers, R. B. ; Yancey, K. B. ; Allen, B. S. / Junctional epidermolysis bullosa. Treatment with phenytoin. In: American Journal of Diseases of Children. 1983 ; Vol. 137, No. 10. pp. 992-994.
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