TY - JOUR
T1 - Junctional Epidermolysis Bullosa
T2 - Treatment With Phenytoin
AU - Guill, M. F.
AU - Wray, B. B.
AU - Rogers, R. B.
AU - Yancey, K. B.
AU - Allen, B. S.
PY - 1983/10
Y1 - 1983/10
N2 - Junctional epidermolysis bullosa (EB) is a rare, heritable, blistering disease of the skin characterized by presence of bullae at birth, lack of scarring of the lesions, and early death. To date there has been no effective treatment for the disease. Phenytoin, which decreases collagenase activity in human skin explants and fibroblast cultures, has been used successfully to treat patients with recessive dystrophic EB. We found a marked decrease in new blister formation in one child with junctional EB during phenytoin therapy.
AB - Junctional epidermolysis bullosa (EB) is a rare, heritable, blistering disease of the skin characterized by presence of bullae at birth, lack of scarring of the lesions, and early death. To date there has been no effective treatment for the disease. Phenytoin, which decreases collagenase activity in human skin explants and fibroblast cultures, has been used successfully to treat patients with recessive dystrophic EB. We found a marked decrease in new blister formation in one child with junctional EB during phenytoin therapy.
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U2 - 10.1001/archpedi.1983.02140360052017
DO - 10.1001/archpedi.1983.02140360052017
M3 - Article
C2 - 6613946
AN - SCOPUS:0020518392
SN - 0002-922X
VL - 137
SP - 992
EP - 994
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 10
ER -