TY - JOUR
T1 - Juvenile polyps and juvenile polyp syndromes in children
T2 - A clinical and endoscopic survey
AU - Hood, Brandy
AU - Bigler, Steven
AU - Bishop, Phyllis
AU - Liu, Hua
AU - Ahmad, Naveed
AU - Renault, MacEy
AU - Nowicki, Michael
PY - 2011/10
Y1 - 2011/10
N2 - In children, most colonic polyps are juvenile polyps with negligible risk for malignant transformation. The exception is juvenile polyposis syndrome (JPS) where there is a risk for developing colon cancer. The authors studied differences in clinical features and colonoscopic findings in children with solitary juvenile polyps (SJP), multiple juvenile polyps (MJP), and JPS. Methods. Children were identified as SJP (1 polyp), MJP (2-4 polyps), or JPS (>5 polyps). Demographic data, laboratory values, family history, and colonoscopic findings were recorded. Results. Children having polypectomy had juvenile polyps (93%), adenomatous polyps (5%), and Peutz-Jegher syndrome (3%). Juvenile polyps were classified as SJP (67%), MJP (16%), and JPS (17%). Children with SJP were younger, were more likely to have polyps limited to the rectosigmoid colon, and had larger polyps than children with MJP and JPS. Anemia was more common in JPS than MJP and SJP. Conclusion. Clinical and endoscopic findings differ between SJP, MJP, and JPS.
AB - In children, most colonic polyps are juvenile polyps with negligible risk for malignant transformation. The exception is juvenile polyposis syndrome (JPS) where there is a risk for developing colon cancer. The authors studied differences in clinical features and colonoscopic findings in children with solitary juvenile polyps (SJP), multiple juvenile polyps (MJP), and JPS. Methods. Children were identified as SJP (1 polyp), MJP (2-4 polyps), or JPS (>5 polyps). Demographic data, laboratory values, family history, and colonoscopic findings were recorded. Results. Children having polypectomy had juvenile polyps (93%), adenomatous polyps (5%), and Peutz-Jegher syndrome (3%). Juvenile polyps were classified as SJP (67%), MJP (16%), and JPS (17%). Children with SJP were younger, were more likely to have polyps limited to the rectosigmoid colon, and had larger polyps than children with MJP and JPS. Anemia was more common in JPS than MJP and SJP. Conclusion. Clinical and endoscopic findings differ between SJP, MJP, and JPS.
KW - immunohistochemical markers
KW - juvenile polyposis syndrome
KW - juvenile polyps
KW - malignant potential
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U2 - 10.1177/0009922811407177
DO - 10.1177/0009922811407177
M3 - Review article
C2 - 21576185
AN - SCOPUS:80053259854
SN - 0009-9228
VL - 50
SP - 910
EP - 915
JO - Clinical Pediatrics
JF - Clinical Pediatrics
IS - 10
ER -