Karyopherins in cancer

Tolga Çağatay, Yuh Min Chook

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.

Original languageEnglish (US)
Pages (from-to)30-42
Number of pages13
JournalCurrent Opinion in Cell Biology
Volume52
DOIs
Publication statusPublished - Jun 1 2018

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology

Cite this