Karyopherins in cancer

Tolga Çağatay; Yuh Min Chook

doi:10.1016/j.ceb.2018.01.006

Karyopherins in cancer

Tolga Çağatay, Yuh Min Chook

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.

Original language	English (US)
Pages (from-to)	30-42
Number of pages	13
Journal	Current Opinion in Cell Biology
Volume	52
DOIs	https://doi.org/10.1016/j.ceb.2018.01.006
State	Published - Jun 1 2018

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2018.01.006

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title = "Karyopherins in cancer",

abstract = "Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.",

author = "Tolga {\c C}ağatay and Chook, {Yuh Min}",

note = "Funding Information: This work is funded by Cancer Prevention Research Institute of Texas (CPRIT) Grants RP150053 and RP170170 (YMC), National Institutes of Health (NIH) Grant R01-GM069909 (YMC), the Welch Foundation Grant I-1532 (YMC) and the University of Texas Southwestern Endowed Scholars Program (YMC). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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AU - Çağatay, Tolga

AU - Chook, Yuh Min

N1 - Funding Information: This work is funded by Cancer Prevention Research Institute of Texas (CPRIT) Grants RP150053 and RP170170 (YMC), National Institutes of Health (NIH) Grant R01-GM069909 (YMC), the Welch Foundation Grant I-1532 (YMC) and the University of Texas Southwestern Endowed Scholars Program (YMC). Publisher Copyright: © 2018 Elsevier Ltd

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N2 - Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.

AB - Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.

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Karyopherins in cancer

Abstract

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