Kassinin and substance P stimulate somatostatin release in the rat

H. G. Guellner, V. Harris, Roger H Unger

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of the tachykinin dodecapeptide kassinin, which has been extracted from the skin of several African frogs, on somatostatin release was examined in the rat and compared with that of the neuropeptide substance P. Equimolar doses of the two peptides were injected intravenously and the animals killed at specified intervals after injection. Somatostatin was measured by a specific radioimmunoassay. Kassinin and substance P had no effect when given in low doses (0.1 and 1.0 μg). However, when administered in a dose of 10.0 μg, both peptides significantly increased plasma somatostatin, by 31 and 22% respectively. These findings suggest that kassinin and substance P have common endocrine actions. The effect on somatostatin release may be specific for tachykinins, since other neuropeptides such as the enkephalins have no effect.

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
JournalClinical science
Volume61
Issue number6
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Medicine(all)

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