TY - JOUR
T1 - Keeping stem cells under control
T2 - New insights into the mechanisms that limit niche-stem cell signaling within the reproductive system
AU - Inaba, Mayu
AU - Yamashita, Yukiko M.
AU - Buszczak, Michael
N1 - Funding Information:
We thank Yamashita and Buszczak lab members for discussions. The research in the Yamashita laboratory is supported by Howard Hughes Medical Institute, National Institutes of Health (1R01GM118308-01). YMY is supported by the MacArthur Foundation. MB is supported by the National Institutes of Health (R01AG047318).
Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Adult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self-renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells undergo self-renewal while their progeny, often located just one cell diameter away from the niche, differentiate. Despite extensive studies on the signaling pathways that operate within stem cells and their niches, how this segregation occurs remains elusive. Here we review recent progress on the characterization of niche-stem cell interactions, with a focus on emerging mechanisms that spatially restrict niche signaling. Mol. Reprod. Dev.
AB - Adult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self-renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells undergo self-renewal while their progeny, often located just one cell diameter away from the niche, differentiate. Despite extensive studies on the signaling pathways that operate within stem cells and their niches, how this segregation occurs remains elusive. Here we review recent progress on the characterization of niche-stem cell interactions, with a focus on emerging mechanisms that spatially restrict niche signaling. Mol. Reprod. Dev.
UR - http://www.scopus.com/inward/record.url?scp=84983656018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983656018&partnerID=8YFLogxK
U2 - 10.1002/mrd.22682
DO - 10.1002/mrd.22682
M3 - Review article
C2 - 27434704
AN - SCOPUS:84983656018
SN - 1040-452X
VL - 83
SP - 675
EP - 683
JO - Molecular Reproduction and Development
JF - Molecular Reproduction and Development
IS - 8
ER -