Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis

Craig J. McClain, Vatsalya Vatsalya, Mack C. Mitchell

Research output: Contribution to journalEditorialpeer-review

3 Scopus citations


ABSTRACT: It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalThe American Journal of Gastroenterology
Issue number1
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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