Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss; Mark P. Goldberg; Dennis W. Choi

doi:10.1016/0006-8993(86)91447-2

Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss, Mark P. Goldberg, Dennis W. Choi

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	Brain Research
Volume	380
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91447-2
State	Published - Aug 13 1986

Keywords

cell culture
cell death
cyanide
glutamate
hypoxia
ketamine

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)91447-2

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title = "Ketamine protects cultured neocortical neurons from hypoxic injury",

abstract = "The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.",

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note = "Funding Information: Wills and Hereditary Disease Foundations, and by a Hartford Fellowship from the John A. Hartford Foundation (to D.W.C.). Funding Information: Yokoyama for expert assistance with cell cultures. Ketamine was a kind gift from Warner-Lambert. This research was supported by Grant NS21628 from the National Institute of Health, grants from the",

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N2 - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

AB - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

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KW - cell death

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KW - glutamate

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Ketamine protects cultured neocortical neurons from hypoxic injury

Abstract

Keywords

ASJC Scopus subject areas

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