Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss, Mark P. Goldberg, Dennis W. Choi

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalBrain Research
Volume380
Issue number1
DOIs
StatePublished - Aug 13 1986

Fingerprint

Brain Hypoxia
General Anesthetics
Ketamine
Cyanides
Atmosphere
Aspartic Acid
Cell Culture Techniques
Pharmacology
Neurons
Wounds and Injuries

Keywords

  • cell culture
  • cell death
  • cyanide
  • glutamate
  • hypoxia
  • ketamine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Ketamine protects cultured neocortical neurons from hypoxic injury. / Weiss, John; Goldberg, Mark P.; Choi, Dennis W.

In: Brain Research, Vol. 380, No. 1, 13.08.1986, p. 186-190.

Research output: Contribution to journalArticle

Weiss, John ; Goldberg, Mark P. ; Choi, Dennis W. / Ketamine protects cultured neocortical neurons from hypoxic injury. In: Brain Research. 1986 ; Vol. 380, No. 1. pp. 186-190.
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