Abstract
Epigenetics represent heritable changes in gene expression that are not due to any alteration in the DNA sequence. One of the best-known epigenetic markers is histone acetylation, which has been shown to be deregulated in neoplastic diseases, including B-cell malignancies, such as Waldenström's Macroglobulinemia (WM), a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a serum monoclonal immunoglobulin M in the circulation. It has been recently demonstrated that microRNAs may be responsible for modulating histone acetylation in WM cells, thus providing the preclinical evidences for using microRNA-based therapeutic strategies in this disease.
Original language | English (US) |
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Pages (from-to) | 109-111 |
Number of pages | 3 |
Journal | Clinical Lymphoma, Myeloma and Leukemia |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research