Keynote review: The adipocyte as a drug discovery target

Andrea R. Nawrocki, Philipp E. Scherer

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

The adipocyte has pleiotropic functions beyond the storage of energy in times of nutrient abundance. Considerable efforts in adipocyte biology within the past ten years have emphasized the important role of adipose tissue in processes as diverse as energy metabolism, inflammation and cancer. Adipocytes are able to communicate with the brain and peripheral tissues implementing metabolic signals such as satiety, food intake and energy expenditure. Despite its huge pharmacological potential, only a small number of clinical applications interfere directly with adipocyte physiology. Here, we want to highlight various areas of adipocyte physiology that have not yet been explored pharmacologically and emphasize some of the limitations associated with these pharmacotherapies.

Original languageEnglish (US)
Pages (from-to)1219-1230
Number of pages12
JournalDrug Discovery Today
Volume10
Issue number18
DOIs
Publication statusPublished - Sep 15 2005

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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