KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri

David J. Hormozdi, Max Q. Arens, Binh Minh Le, Richard S. Buller, Eugene Agapov, Gregory A. Storch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Studies have reported the presence of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) in respiratory secretions of young patients. So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups. Methods: A retrospective study comparing clinical aspects of KIPyV-positive patients with respiratory syncytial virus (RSV)-positive, WUPyV-positive, and respiratory-virus negative patients. Using real-time polymerase chain reaction, 2599 respiratory samples from patients ranging from 1 day to 88 years of age were tested for KIPyV. Electronic medical records were reviewed for 65 cases, for a comparison group consisting of 195 patients negative for common respiratory viruses, and for 56 WUPyV-positive patients drawn from the same population. Twelve patients testing positive for KIPyV as the sole pathogen were matched to 36 RSV-positive patients and clinical features of both groups were compared. Results: Seventy-two (2.8%) respiratory samples were positive for KIPyV. Another virus was detected in 71% of the KIPyV-positive samples. Analysis showed no statistically significant differences in clinical manifestations between KIPyV-positive patients and patients negative for common respiratory viruses, however, clinical characteristics of KIPyV-positive patients were less severe than those of patients positive for RSV. KIPyVpositive patients >3 years of age were usually immunocompromised in contrast to the younger children with KIPyV. Conclusions: This study did not demonstrate a link between KIPyV infection and symptomatic respiratory disease. Patients positive for KIPyV exhibited less severe clinical symptoms than patients positive for RSV.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalPediatric Infectious Disease Journal
Volume29
Issue number4
DOIs
StatePublished - Apr 2010

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Polyomavirus
Respiratory System
Respiratory Syncytial Viruses
Viruses
Polyomavirus Infections
Respiratory Tract Diseases
Electronic Health Records

Keywords

  • Human polyomavirus
  • KI polyomavirus
  • KIPyV
  • Respiratory tract disease
  • WUPyV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri. / Hormozdi, David J.; Arens, Max Q.; Le, Binh Minh; Buller, Richard S.; Agapov, Eugene; Storch, Gregory A.

In: Pediatric Infectious Disease Journal, Vol. 29, No. 4, 04.2010, p. 329-333.

Research output: Contribution to journalArticle

Hormozdi, David J. ; Arens, Max Q. ; Le, Binh Minh ; Buller, Richard S. ; Agapov, Eugene ; Storch, Gregory A. / KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri. In: Pediatric Infectious Disease Journal. 2010 ; Vol. 29, No. 4. pp. 329-333.
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abstract = "Background: Studies have reported the presence of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) in respiratory secretions of young patients. So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups. Methods: A retrospective study comparing clinical aspects of KIPyV-positive patients with respiratory syncytial virus (RSV)-positive, WUPyV-positive, and respiratory-virus negative patients. Using real-time polymerase chain reaction, 2599 respiratory samples from patients ranging from 1 day to 88 years of age were tested for KIPyV. Electronic medical records were reviewed for 65 cases, for a comparison group consisting of 195 patients negative for common respiratory viruses, and for 56 WUPyV-positive patients drawn from the same population. Twelve patients testing positive for KIPyV as the sole pathogen were matched to 36 RSV-positive patients and clinical features of both groups were compared. Results: Seventy-two (2.8{\%}) respiratory samples were positive for KIPyV. Another virus was detected in 71{\%} of the KIPyV-positive samples. Analysis showed no statistically significant differences in clinical manifestations between KIPyV-positive patients and patients negative for common respiratory viruses, however, clinical characteristics of KIPyV-positive patients were less severe than those of patients positive for RSV. KIPyVpositive patients >3 years of age were usually immunocompromised in contrast to the younger children with KIPyV. Conclusions: This study did not demonstrate a link between KIPyV infection and symptomatic respiratory disease. Patients positive for KIPyV exhibited less severe clinical symptoms than patients positive for RSV.",
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