Kidney agingg-inevitable or preventable?

Devasmita Choudhury, Moshe Levi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The aging process affects all organs, including the kidneys. As part of this process, progressive scarring and a measurable decline in renal function occur in most people over time. The improved understanding of the processes that can lead to and/or hasten scarring and loss of renal function over time parallels advances in our understanding of the aging process. Clinical factors, including hypertension, diabetes mellitus, obesity, abnormal lipid levels and vitamin D deficiency, have been associated with increasing renal sclerosis with age. In addition, tissue factors such as angiotensin II, advanced glycation end products, oxidative stress and Klotho are associated with renal aging. These associations and possible interventions, including the control of blood pressure, blood sugar, weight, diet and calorie restriction might make renal aging more preventable than inevitable.

Original languageEnglish (US)
Pages (from-to)706-717
Number of pages12
JournalNature Reviews Nephrology
Volume7
Issue number12
DOIs
StatePublished - Dec 2011

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Kidney
Cicatrix
Advanced Glycosylation End Products
Vitamin D Deficiency
Thromboplastin
Sclerosis
Angiotensin II
Blood Glucose
Diabetes Mellitus
Oxidative Stress
Obesity
Diet
Blood Pressure
Hypertension
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Kidney agingg-inevitable or preventable? / Choudhury, Devasmita; Levi, Moshe.

In: Nature Reviews Nephrology, Vol. 7, No. 12, 12.2011, p. 706-717.

Research output: Contribution to journalArticle

Choudhury, Devasmita ; Levi, Moshe. / Kidney agingg-inevitable or preventable?. In: Nature Reviews Nephrology. 2011 ; Vol. 7, No. 12. pp. 706-717.
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