Kidney stones 2012: Pathogenesis, diagnosis, and management

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Context: The pathogenetic mechanisms of kidney stone formation are complex and involve both metabolic and environmental risk factors. Over the past decade, major advances have been made in the understanding of the pathogenesis, diagnosis, and treatment of kidney stone disease. Evidence Acquisition and Synthesis: Both original and review articles were found via PubMed search reporting on pathophysiology, diagnosis, and management of kidney stones. These resources were integrated with the authors' knowledge of the field. Conclusion: Nephrolithiasis remains a major economic and health burden worldwide. Nephrolithiasis is considered a systemic disorder associated with chronic kidney disease, bone loss and fractures, increased risk of coronary artery disease, hypertension, type 2 diabetes mellitus, and the metabolic syndrome. Further understanding of the pathophysiological link between nephrolithiasis and these systemic disorders is necessary for the development of new therapeutic options.

Original languageEnglish (US)
Pages (from-to)1847-1860
Number of pages14
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number6
DOIs
StatePublished - Jun 2012

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Nephrolithiasis
Kidney Calculi
Bone Fractures
Kidney Diseases
Medical problems
Chronic Renal Insufficiency
PubMed
Type 2 Diabetes Mellitus
Coronary Artery Disease
Bone
Economics
Health
Hypertension
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Kidney stones 2012 : Pathogenesis, diagnosis, and management. / Sakhaee, Khashayar; Maalouf, Naim M.; Sinnott, Bridget.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 6, 06.2012, p. 1847-1860.

Research output: Contribution to journalArticle

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