Kiss your tail goodbye: The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology

Alan R. Godwin, Shihoko Kojima, Carla B. Green, Jeffrey Wilusz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appear to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. The goal of this review is to provide an in depth biochemical and biological perspective of the PARN, Nocturnin and Angel deadenylases. Understanding the shared and unique roles of these enzymes in cell biology will provide important insights into numerous aspects of the post-transcriptional control of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number6-7
DOIs
StatePublished - Jun 2013

Fingerprint

Gene expression
Messenger RNA
Enzymes
Cytology
RNA
Gene Expression
Level control
RNA Stability
Eukaryotic Cells
Quality Control
Quality control
Cell Biology
nocturnin
mRNA deadenylase

Keywords

  • Deadenylase
  • MRNA turnover
  • Poly(A) shortening

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Kiss your tail goodbye : The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology. / Godwin, Alan R.; Kojima, Shihoko; Green, Carla B.; Wilusz, Jeffrey.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1829, No. 6-7, 06.2013, p. 571-579.

Research output: Contribution to journalArticle

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