Kiss your tail goodbye: The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology

Alan R. Godwin, Shihoko Kojima, Carla B. Green, Jeffrey Wilusz

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appear to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. The goal of this review is to provide an in depth biochemical and biological perspective of the PARN, Nocturnin and Angel deadenylases. Understanding the shared and unique roles of these enzymes in cell biology will provide important insights into numerous aspects of the post-transcriptional control of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number6-7
DOIs
StatePublished - Jun 2013

Keywords

  • Deadenylase
  • MRNA turnover
  • Poly(A) shortening

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

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