Klotho, an aging-suppressor gene

Kevin P. Rosenblatt, Makoto Kuro-o

Research output: Contribution to journalArticle

1 Scopus citations


Suppression of aging and its effects is a far-reaching dream of human beings. To turn this dream into a scientific reality, it is essential to understand the molecular mechanisms that underlie the aging process. A coherent understanding of these mechanisms is expected to allow us to develop rational strategies for slowing the aging process, which is the most significant risk factor for many age-related disorders including diabetes, heart attack, stroke, osteoporosis, cancer, and dementia. Therefore, any remedy against the progression of aging may reduce and/or delay premature death and disability caused by multiple age-related diseases simultaneously. This could lead to a tremendous increase in both the length and quality of human life.

Original languageEnglish (US)
Pages (from-to)191-203
Number of pages13
JournalHormone Research
Issue numberSUPPL. 1
StatePublished - Feb 1 2007


  • FGF signaling
  • Insulin signaling oxidative stress
  • Klotho, aging

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Rosenblatt, K. P., & Kuro-o, M. (2007). Klotho, an aging-suppressor gene. Hormone Research, 67(SUPPL. 1), 191-203. https://doi.org/10.1159/000097581