Klotho, stem cells, and aging

Ao Bian, Javier A. Neyra, Ming Zhan, Ming C Hu

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt. Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease. The klotho protein may be a promising therapeutic agent for aging and aging-related disorders.

Original languageEnglish (US)
Pages (from-to)1233-1243
Number of pages11
JournalClinical interventions in aging
Volume10
DOIs
StatePublished - Aug 4 2015

Keywords

  • Aging
  • Cell senescence
  • Klotho
  • Stem cells
  • Wnt

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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