Knowing in your heart what's right

Deepak Srivastava, Eric N. Olson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

During heart formation in all vertebrate species, the linear heart tube undergoes rightward looping followed by the formation of the atrial and ventricular chambers. The direction of cardiac looping is determined in part by the asymmetric expression of members of the transforming growth factor β family across the left-right axis of the embryo. The basic helix-loop-helix (bHLH) transcription factors dHAND and eHAND are expressed in the heart tube within specific cardiogenic precursors destined to form the right and left ventricular regions, respectively, and loss-of-function experiments have demonstrated the importance of these factors for looping morphogenesis and ventricular development. We propose a model in which the HAND gene products interpret asymmetric positional information in the developing heart and participate in transcriptional programmes that control development of the right and left ventricular compartments of the heart.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalTrends in Cell Biology
Volume7
Issue number11
DOIs
StatePublished - Nov 1997

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Basic Helix-Loop-Helix Transcription Factors
Transforming Growth Factors
Morphogenesis
Vertebrates
Embryonic Structures
Genes
Direction compound

ASJC Scopus subject areas

  • Cell Biology

Cite this

Knowing in your heart what's right. / Srivastava, Deepak; Olson, Eric N.

In: Trends in Cell Biology, Vol. 7, No. 11, 11.1997, p. 447-453.

Research output: Contribution to journalArticle

Srivastava, Deepak ; Olson, Eric N. / Knowing in your heart what's right. In: Trends in Cell Biology. 1997 ; Vol. 7, No. 11. pp. 447-453.
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