Kristallstrukturanalyse und molekülmodell des menschlichen c3a-anaphylatoxins

R. Huber, H. Scholze, E. P. Paques, J. Deisenhofer

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Human anaphylatoxin C3a, derived from complement component C3 has been crystallized and its crystal structure determined at 3.2 A resolution based on multiple isomorphous replacement. The electron density map was interpretable in terms of the known chemical sequence and a molecular model constructed. The molecule has dimensions of 42 x 22 x 16 A. It resembles a drumstick. It is constructed from two helical segments Tyr15 to Met27 and Gly46 to Ser71 connected by a loop. Residues 1 to 14 are flexible. The C-terminal residues are in irregular conformation. The crystal structure analysis establishes the disulphide linkages as Cys22-Cys49, Cys23-Cys56, Cys36-Cys57.

Original languageEnglish (US)
Pages (from-to)1389-1400
Number of pages12
JournalHoppe-Seyler's Zeitschrift fur Physiologische Chemie
Volume361
Issue number2
DOIs
StatePublished - 1980

Keywords

  • Anaphylatoxin
  • complement
  • crystal structure

ASJC Scopus subject areas

  • Biochemistry

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